INT149700

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.69
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cd86)
Anatomy Link Frequency
CD86 1
T cells 1
Cd86 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
abatacept 6 99.92 Very High Very High Very High
rheumatoid arthritis 2 94.88 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 2 94.88 High High
Autoimmune Disease 6 81.84 Quite High
Organ Transplantation 2 79.92 Quite High
Disease 2 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Belatacept (LEA29Y), currently enrolling phase III trials in renal transplantation, was rationally designed from abatacept to bind with more avidity to CD86, providing the more potent immunosuppressive properties required for immunosuppression in transplantation.
CD86 Binding (bind) of in CD86 associated with abatacept
1) Confidence 0.33 Published 2008 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 18269922 Disease Relevance 0.40 Pain Relevance 0.30
The selective costimulation inhibitor abatacept (cytotoxic T lymphocyte-associated antigen 4-Ig) binds to CD80 and CD86 on antigen-presenting cells, blocking interaction with CD28 on T cells, and is approved for the treatment of moderate to severe rheumatoid arthritis.
CD86 Binding (binds) of in T cells associated with rheumatoid arthritis and abatacept
2) Confidence 0.24 Published 2008 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 18269922 Disease Relevance 0.28 Pain Relevance 0.23

General Comments

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