INT149737

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.00
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
pore 2
external 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 4 95.88 Very High Very High Very High
tetrodotoxin 1 83.56 Quite High
sodium channel 1 56.32 Quite High
ischemia 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 25 100.00 Very High Very High Very High
Stress 6 99.88 Very High Very High Very High
Shock 1 92.80 High High
Anaerobic Bacterial Infections 1 91.88 High High
Death 4 86.08 High High
Hypoxia 52 78.00 Quite High
Cv General 3 Under Development 1 63.36 Quite High
Coronary Heart Disease 2 62.76 Quite High
Myocardial Infarction 4 11.48 Low Low
Injury 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDPH-SNP synergism remained intact in the absence of external Ca2+, indicating that regulation of Ca2+ influx was not a requirement for the manifestation of this interaction.
Neg (not) Positive_regulation (requirement) of Regulation (regulation) of Ca2 in external
1) Confidence 0.58 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19186210 Disease Relevance 0.13 Pain Relevance 0
Mitochondria play essential roles in cell energy production, oxidative stress, and regulation of apoptosis.46 Intracellular Ca2+ overload could promote the opening of mitochondrial permeability transition pore (MPT), leading to a sudden ??
Positive_regulation (promote) of Regulation (regulation) of Ca2 in pore associated with stress and apoptosis
2) Confidence 0.29 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.78 Pain Relevance 0
These results establish that the effect of the toxin on both intracellular Ca2+ and IP3 levels occurs via a membrane potential sensor instead of directly by Na+ flux and supports the notion of a train of action potentials being more efficient as a stimulus than sustained depolarization, suggesting that tetanus is the physiological stimulus for the IP3-dependent calcium signal involved in regulation of gene expression.
Positive_regulation (occurs) of Regulation (effect) of Ca2 associated with action potential and anaerobic bacterial infections
3) Confidence 0.25 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18276006 Disease Relevance 0.09 Pain Relevance 0.27

General Comments

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