INT149739

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 7.22
Pain Relevance 5.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
neurons 6
brain 4
epithelial cells 2
heart 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 70 100.00 Very High Very High Very High
qutenza 255 99.80 Very High Very High Very High
opioid receptor 110 99.64 Very High Very High Very High
fibrosis 21 98.96 Very High Very High Very High
dorsal root ganglion 63 98.56 Very High Very High Very High
adenocard 28 97.40 Very High Very High Very High
Action potential 43 97.12 Very High Very High Very High
Kinase C 70 96.88 Very High Very High Very High
sodium channel 4 95.24 Very High Very High Very High
imagery 43 93.96 High High
Disease Link Frequency Relevance Heat
Hypoxia 999 100.00 Very High Very High Very High
Diabetic Cardiomyopathies 105 100.00 Very High Very High Very High
Stress 53 99.80 Very High Very High Very High
Cystic Fibrosis 13 99.52 Very High Very High Very High
Diabetes Complications 2 99.16 Very High Very High Very High
Diabetes Mellitus 182 98.92 Very High Very High Very High
Ganglion Cysts 98 98.56 Very High Very High Very High
Overactive Bladder 18 95.96 Very High Very High Very High
Cancer 85 91.80 High High
Anaerobic Bacterial Infections 1 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of anoxia on Ca2+ clearance
Regulation (Effects) of Gene_expression (clearance) of Ca2 associated with hypoxia
1) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.73 Pain Relevance 0
Effects of anoxia on resting [Ca2+]i in DRG neurons
Regulation (Effects) of Gene_expression (resting) of Ca2 in neurons associated with hypoxia
2) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.40 Pain Relevance 0.10
Effects of anoxia on cytosolic Ca2+ clearance
Regulation (Effects) of Gene_expression (clearance) of Ca2 associated with hypoxia
3) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.35 Pain Relevance 0
Interactions among the effects of anoxia on Ca2+ clearance, mitochondrial Ca2+ buffering, and ER Ca2+ uptake
Regulation (effects) of Gene_expression (clearance) of Ca2 associated with hypoxia
4) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.48 Pain Relevance 0
Interactions among the effects of anoxia on Ca2+ clearance, mitochondrial Ca2+ buffering, and ER Ca2+ uptake
Regulation (effects) of Gene_expression (uptake) of Ca2 associated with hypoxia
5) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.49 Pain Relevance 0
Effects of anoxia on ER Ca2+ stores
Regulation (Effects) of Gene_expression (stores) of Ca2 associated with hypoxia
6) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.64 Pain Relevance 0
In the present study, Gd3+ inhibited both voltage-activated Ca2+ entry and capsaicin-evoked Ca2+ influx, but we could only inhibit capsaicin-evoked Ca2+ transients with Gd3+ concentrations of 500 ?
Regulation (voltage) of Gene_expression (entry) of Ca2 associated with qutenza
7) Confidence 0.37 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0 Pain Relevance 0.71
(a) To point out the eventual regulatory role on Ca2+ oscillations of a high dose of uridine 5?
Regulation (role) of Gene_expression (oscillations) of Ca2
8) Confidence 0.36 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0
M zolmitriptan without Ca2+ blockers) in Fig. 1c, suggesting a possibility that Ca2+ channels sensitive to ?
Spec (possibility) Regulation (sensitive) of Gene_expression (channels) of Ca2
9) Confidence 0.33 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0 Pain Relevance 0.08
The concentration of cytosolic free Ca2+ ions ([Ca2+]c) is a general intracellular messenger regulating a variety of different cellular processes, including membrane potentials and gene expression.
Regulation (regulating) of Gene_expression (expression) of Ca2
10) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.28
The effects of acute and chronic morphine treatments on the expression of Ca2+/calmodulin dependent protein kinase II (CaMK II) gene in rat brain were investigated using in situ hybridization histochemistry.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of Ca2 in brain associated with morphine
11) Confidence 0.30 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18408996 Disease Relevance 0.08 Pain Relevance 0.48
Chronic, but not acute morphine treatment, up-regulates alpha-Ca2+/calmodulin dependent protein kinase II gene expression in rat brain.
Regulation (regulates) of Gene_expression (expression) of Ca2 in brain associated with morphine
12) Confidence 0.26 Published 2008 Journal Neurochem. Res. Section Title Doc Link 18408996 Disease Relevance 0.08 Pain Relevance 0.74
Gene expression of proteins influencing Ca2+ homeostasis
Regulation (influencing) of Gene_expression (homeostasis) of Ca2
13) Confidence 0.26 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 1.08 Pain Relevance 0
ATP, UTP, or reduced extracellular pH elicited Ca2+ transients and inward currents (Erev ?
Regulation (elicited) of Gene_expression (transients) of Ca2
14) Confidence 0.24 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Abstract Doc Link PMC2536873 Disease Relevance 0.31 Pain Relevance 0.14
These results establish that the effect of the toxin on both intracellular Ca2+ and IP3 levels occurs via a membrane potential sensor instead of directly by Na+ flux and supports the notion of a train of action potentials being more efficient as a stimulus than sustained depolarization, suggesting that tetanus is the physiological stimulus for the IP3-dependent calcium signal involved in regulation of gene expression.
Regulation (effect) of Gene_expression (levels) of Ca2 associated with action potential and anaerobic bacterial infections
15) Confidence 0.23 Published 2008 Journal Cell Calcium Section Abstract Doc Link 18276006 Disease Relevance 0.09 Pain Relevance 0.27
Only a small fraction of short-term cultured hippocampal neurons (ca 1 week in vitro) exhibited changes in intracellular Ca2+ level after A?
Regulation (intracellular) of Gene_expression (level) of Ca2 in neurons
16) Confidence 0.13 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2515900 Disease Relevance 0.52 Pain Relevance 0.05
[Ca2+]/[Ca2+]0, where [Ca2+]0 is basal intracellular Ca2+ level and ?
Regulation (intracellular) of Gene_expression (level) of Ca2
17) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0 Pain Relevance 0.03
[Ca2+]/[Ca2+]0, where [Ca2+]0 is basal intracellular Ca2+ level and ?
Regulation (intracellular) of Gene_expression (level) of Ca2
18) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0 Pain Relevance 0.03
To investigate the influence of breviscapine on the cardiac structure and function in rats with DCM, as well as the expression of PKC and Ca2+ cycling proteins, type 2 diabetic rats were treated with breviscapine for 6 weeks, and invasive cardiac function and echocardiographic parameters were measured, while heart tissue was obtained for electron microscope study.
Spec (investigate) Regulation (influence) of Gene_expression (expression) of Ca2 in heart associated with diabetes mellitus and diabetic cardiomyopathies
19) Confidence 0.10 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 0.99 Pain Relevance 0.05
LPI elicits biphasic Ca2+ elevation, accompanied by diverse changes in membrane potential
Regulation (biphasic) of Gene_expression (elevation) of Ca2
20) Confidence 0.09 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0 Pain Relevance 0

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