INT149747

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.46
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
liver 2
Pck1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 14 88.64 High High
Opioid 32 82.96 Quite High
narcan 7 64.96 Quite High
cINOD 1 63.24 Quite High
ischemia 1 26.00 Quite Low
antagonist 8 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 106 99.16 Very High Very High Very High
Apoptosis 9 98.40 Very High Very High Very High
Targeted Disruption 5 71.60 Quite High
Cardiovascular Disease 1 65.24 Quite High
INFLAMMATION 2 63.00 Quite High
Myocardial Infarction 1 54.76 Quite High
Injury 2 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Roflumilast increased Epac1/GTP-Rap1 and the protective effect was abolished by Epac1 siRNA transfection, demonstrating that Epac signaling was also involved in this protective response.
Negative_regulation (abolished) of Positive_regulation (increased) of GTP
1) Confidence 0.42 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18276108 Disease Relevance 0.77 Pain Relevance 0.06
Similar treatment with tetrandrine reversed the elevated mRNA and protein levels of PEPCK in the liver of STZ-diabetic rats.
Negative_regulation (reversed) of Positive_regulation (elevated) of PEPCK in liver associated with diabetes mellitus
2) Confidence 0.34 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC516459 Disease Relevance 0.69 Pain Relevance 0.34

General Comments

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