INT149754

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.00
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
neuronal 4
ganglia 2
primary sensory neurons 2
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 88.80 High High
antagonist 21 85.96 High High
ischemia 11 84.72 Quite High
trigeminal ganglion 150 80.28 Quite High
dorsal root ganglion 49 74.40 Quite High
Hippocampus 13 74.24 Quite High
cerebral cortex 3 72.20 Quite High
agonist 40 54.32 Quite High
Pain 43 25.00 Low Low
Pyramidal cell 1 13.68 Low Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 5 99.98 Very High Very High Very High
Ganglion Cysts 241 97.76 Very High Very High Very High
Injury 7 96.88 Very High Very High Very High
Heart Injuries 1 92.92 High High
Heart Rate Under Development 2 89.00 High High
Frailty 1 88.80 High High
Nociception 32 86.40 High High
Cv General 4 Under Development 1 84.72 Quite High
Coronary Artery Disease 2 81.92 Quite High
Apoptosis 8 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The myocardial ischemic injury increased the expression of P2X3 immunoreactivity and mRNA in nodose ganglia.
Positive_regulation (increased) of Transcription (expression) of P2X3 in ganglia associated with myocardial infarction
1) Confidence 0.44 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 1.14 Pain Relevance 0.15
Fig 2A shows that, when comparing samples containing an equal amount of the housekeeping gene GAPDH mRNA, there was significant upregulation of P2X3 and TRPV1 transcripts for rat and mouse neurons in vitro with respect to the ganglion after normalization for the neuronal-specific ?
Positive_regulation (upregulation) of Transcription (transcripts) of P2X3 in neuronal associated with ganglion cysts
2) Confidence 0.42 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.50 Pain Relevance 0.04
Fig 2A shows that, when comparing samples containing an equal amount of the housekeeping gene GAPDH mRNA, there was significant upregulation of P2X3 and TRPV1 transcripts for rat and mouse neurons in vitro with respect to the ganglion after normalization for the neuronal-specific ?
Positive_regulation (upregulation) of Transcription (transcripts) of P2X3 in neuronal associated with ganglion cysts
3) Confidence 0.30 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.50 Pain Relevance 0.04
The increased expression of P2X3 receptor mRNA in intact neurons indicates a role of this subtype in the post-injury pathomechanism in primary sensory neurons [167].
Positive_regulation (increased) of Transcription (expression) of P2X3 in primary sensory neurons associated with injury
4) Confidence 0.30 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.78 Pain Relevance 0.32
Increasing the concentration of the P2X3 GST fusion proteins from 1 ?
Positive_regulation (Increasing) of Transcription (concentration) of P2X3
5) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox