INT149755

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.28
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
neuronal 3
ganglia 2
neurons 1
primary sensory neurons 1
motor neurons 1
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 26 95.80 Very High Very High Very High
antagonist 46 95.60 Very High Very High Very High
ischemia 28 91.56 High High
Pain 110 90.12 High High
Spinal cord 14 88.80 High High
trigeminal ganglion 375 87.84 High High
Peripheral nervous system 2 81.40 Quite High
agonist 92 78.64 Quite High
dexamethasone 3 77.24 Quite High
dorsal root ganglion 73 74.40 Quite High
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 10 99.76 Very High Very High Very High
Myocardial Infarction 25 99.70 Very High Very High Very High
Heart Rate Under Development 10 98.64 Very High Very High Very High
Heart Injuries 5 98.64 Very High Very High Very High
Ganglion Cysts 553 97.76 Very High Very High Very High
Injury 16 96.88 Very High Very High Very High
Nociception 77 94.32 High High
Coronary Artery Disease 10 91.56 High High
Pain 127 90.12 High High
Apoptosis 18 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The myocardial ischemic injury increased the expression of P2X3 immunoreactivity and mRNA in nodose ganglia.
Transcription (expression) of P2X3 in ganglia associated with myocardial infarction
1) Confidence 0.60 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 1.13 Pain Relevance 0.15
In rats treated with A-317491, the expression of P2X3 immunoreactivity and mRNA in nodose ganglia was reduced.
Transcription (expression) of P2X3 in ganglia
2) Confidence 0.60 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 1.11 Pain Relevance 0.12
The expression of P2X3 immunoreactivity, mRNA and protein were analyzed by immunohistochemistry, in situ hybridization and western blotting.
Spec (analyzed) Transcription (expression) of P2X3
3) Confidence 0.60 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 0.93 Pain Relevance 0.16
The expression of P2X3 mRNA and protein in the ischemic injury heart were higher than that in the naive heart as control.
Transcription (expression) of P2X3 in heart associated with heart injuries
4) Confidence 0.46 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 1.13 Pain Relevance 0.16
A-317491 reduced the expression of P2X3 mRNA and protein in the myocardial ischemic injury.
Transcription (expression) of P2X3 associated with myocardial infarction
5) Confidence 0.46 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18276198 Disease Relevance 1.14 Pain Relevance 0.15
Transient changes in P2X3 but not TRPV1 mRNA expression in rat after prenatal exposure to glucocorticoids.
Transcription (expression) of P2X3
6) Confidence 0.44 Published 2008 Journal Auton Neurosci Section Title Doc Link 18541457 Disease Relevance 0.09 Pain Relevance 0.33
Fig 2A shows that, when comparing samples containing an equal amount of the housekeeping gene GAPDH mRNA, there was significant upregulation of P2X3 and TRPV1 transcripts for rat and mouse neurons in vitro with respect to the ganglion after normalization for the neuronal-specific ?
Transcription (transcripts) of P2X3 in neuronal associated with ganglion cysts
7) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.50 Pain Relevance 0.04
Specific TaqMan assays for mouse and rat target mRNA encoding P2X3, P2X2 and TRPV1, neuronal specific ?
Transcription (encoding) of P2X3 in neuronal
8) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.18 Pain Relevance 0.09
In particular, P2X3 mRNA showed a peak at 24 h (1.29 fold, P < 0.05, and 1.39 fold, P < 0.01, for rat and mouse, respectively).
Transcription (showed) of P2X3
9) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.47 Pain Relevance 0.04
Because P2X2 and TRPV1 receptors are also expressed in non-neuronal cells, while the P2X3 receptor is not [16,17], it was important to assess the contribution of P2X2, P2X3 and TRPV1 mRNAs in 3 week-old cultures, containing no neurons (?
Transcription (contribution) of P2X3 in neurons
10) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.24 Pain Relevance 0.03
For real time PCR, the relative mRNA expression of P2X3, P2X2 and TRPV1 in the different samples was normalized to the neuronal ?
Transcription (expression) of P2X3 in neuronal
11) Confidence 0.41 Published 2006 Journal Mol Pain Section Body Doc Link PMC1448213 Disease Relevance 0.32 Pain Relevance 0.25
The increased expression of P2X3 receptor mRNA in intact neurons indicates a role of this subtype in the post-injury pathomechanism in primary sensory neurons [167].
Transcription (expression) of P2X3 in primary sensory neurons associated with injury
12) Confidence 0.31 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.78 Pain Relevance 0.32
Increasing the concentration of the P2X3 GST fusion proteins from 1 ?
Transcription (concentration) of P2X3
13) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.07 Pain Relevance 0.04
P2X3 receptor immunoreactivity was detected in cranial motor neurons as early as on E11, when neurons exited the cell cycle and started axon outgrowth, as well as postnatally on days 7 and 14 (P7 and P14) [56, 60].
Transcription (detected) of P2X3 in motor neurons
14) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.17 Pain Relevance 0.23

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