INT149756

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 9.53
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
liver 1
hip 1
platelets 1
ten (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
corticosteroid 5 98.72 Very High Very High Very High
depression 5 97.16 Very High Very High Very High
anticonvulsant 18 90.16 High High
Inflammatory response 1 77.92 Quite High
withdrawal 5 63.96 Quite High
headache 1 62.88 Quite High
Paracetamol 1 62.44 Quite High
diclofenac 2 61.40 Quite High
cINOD 8 60.60 Quite High
ketamine 8 50.00 Quite Low
Disease Term Frequency Confidence Heat
Urticaria 3 100.00 Very High Very High Very High
Staphylococcus Infection 192 100.00 Very High Very High Very High
Syndrome 80 100.00 Very High Very High Very High
Femoral Fractures 3 99.98 Very High Very High Very High
Graft Vs Host Disease 90 99.84 Very High Very High Very High
Death 10 99.84 Very High Very High Very High
Acute Generalized Exanthematous Pustulosis 9 99.78 Very High Very High Very High
Increased Venous Pressure Under Development 2 99.48 Very High Very High Very High
Hepatotoxicity 13 99.44 Very High Very High Very High
Thrombocytopenia 9 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Ten men and ten women received a 2-h S(+)-ketamine infusion.
Gene_expression (men) of Ten
1) Confidence 0.58 Published 2009 Journal Anesthesiology Section Body Doc Link 19741495 Disease Relevance 0 Pain Relevance 0
METHODS: Ten men and ten women received a 2-h S(+)-ketamine infusion.
Gene_expression (women) of ten
2) Confidence 0.58 Published 2009 Journal Anesthesiology Section Body Doc Link 19741495 Disease Relevance 0 Pain Relevance 0
METHODS: Ten countries participated in three rounds of discussions and votes concerning the management of AS.
Gene_expression (countries) of Ten
3) Confidence 0.58 Published 2008 Journal Rheumatology (Oxford) Section Body Doc Link 18276738 Disease Relevance 0.09 Pain Relevance 0
Thirteen children developed entry site irritation.22 Similarly, Narayanan et al. found good outcome in 79 femoral fractures stabilized with TEN.3
Gene_expression (stabilized) of TEN associated with femoral fractures
4) Confidence 0.58 Published 2007 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2989518 Disease Relevance 0.47 Pain Relevance 0
RESULTS: Ten hip fractures were diagnosed by MRI.
Gene_expression (fractures) of Ten in hip
5) Confidence 0.29 Published 2009 Journal J Ultrasound Med Section Body Doc Link 19854958 Disease Relevance 0.08 Pain Relevance 0
Among candidate etiologic agents, sulfa and beta-lactam antibiotics stood out: both of these had been started within the 3 weeks prior to the patient's presentation with TEN and both are known to be frequently implicated in TEN.1,2

DISCUSSION

Gene_expression (presentation) of TEN associated with staphylococcus infection
6) Confidence 0.10 Published 2006 Journal Journal of Burns and Wounds Section Body Doc Link PMC1687152 Disease Relevance 1.04 Pain Relevance 0
In the absence of such data, it is impossible to differentiate between the diagnoses of TEN and GVHD in the weeks following orthotopic liver transplantation.
Gene_expression (diagnoses) of TEN in liver associated with staphylococcus infection and graft vs host disease
7) Confidence 0.10 Published 2006 Journal Journal of Burns and Wounds Section Body Doc Link PMC1687152 Disease Relevance 1.04 Pain Relevance 0.03
Corticosteroids, another treatment used in the past, probably do not alter the progression of TEN and increase the risk of infection.18,19 The current standard of care for TEN is supportive.
Gene_expression (progression) of TEN associated with staphylococcus infection, corticosteroid and infection
8) Confidence 0.10 Published 2006 Journal Journal of Burns and Wounds Section Body Doc Link PMC1687152 Disease Relevance 1.09 Pain Relevance 0.08
Death in the TEN patient is usually a result of septic shock/multiple organ failure.6
Gene_expression (patient) of TEN associated with multiple organ failure, staphylococcus infection, sepsis and death
9) Confidence 0.10 Published 2006 Journal Journal of Burns and Wounds Section Body Doc Link PMC1687152 Disease Relevance 1.65 Pain Relevance 0.05
Future work may, however, produce a specific therapy for either TEN or GVHD.
Gene_expression (produce) of TEN associated with staphylococcus infection and graft vs host disease
10) Confidence 0.09 Published 2006 Journal Journal of Burns and Wounds Section Body Doc Link PMC1687152 Disease Relevance 0.80 Pain Relevance 0.03
SJS or TEN from NSAIDs and cyclooxygenase-2-selective NSAIDs appears to affect the same patient population as other medications that cause SJS or TEN.
Gene_expression (cause) of TEN
11) Confidence 0.08 Published 2010 Journal Am J Health Syst Pharm Section Body Doc Link 20101062 Disease Relevance 0.13 Pain Relevance 0
Severe adverse events included TEN, SJS, severe liver dysfunction (ALT >300 IU/ml) and severe thrombocytopenia (platelets <50,000/?
Gene_expression (included) of TEN in platelets associated with staphylococcus infection, syndrome, thrombocytopenia and hepatotoxicity
12) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906798 Disease Relevance 0.89 Pain Relevance 0.06
Both real competitive PCR (rcPCR) and real-time PCR were used to validate expression profiles for ten of the interesting differentially expressed genes from the microarray experiment.
Gene_expression (expressed) of ten
13) Confidence 0.02 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2204014 Disease Relevance 0 Pain Relevance 0
Though had not been investigated in SJS/TEN, LTA was co-cited with HLA-C [27], implying a putative functional linkage of this gene to SJS/TEN through HLA-C.
Gene_expression (cited) of TEN associated with staphylococcus infection and syndrome
14) Confidence 0.01 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2704868 Disease Relevance 1.43 Pain Relevance 0.04
However, patch test sensitivity varies with the type of eruption (higher in eczematous, maculopapular, and AGEP; lower in urticaria, SJS, and TEN; and nil in vasculitis), [6,48] as well as with the drug involved (higher with diltiazem, abacavir, ?
Gene_expression (urticaria) of TEN associated with staphylococcus infection, urticaria, acute generalized exanthematous pustulosis, syndrome and increased venous pressure under development
15) Confidence 0.01 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868884 Disease Relevance 0.81 Pain Relevance 0.25

General Comments

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