INT14976

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Context Info
Confidence 0.24
First Reported 1986
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.75
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adrb2) plasma membrane (Adrb2) nucleus (Adrb2)
cytoplasm (Adrb2) signal transducer activity (Adrb2)
Anatomy Link Frequency
nerve 1
Adrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 7 100.00 Very High Very High Very High
agonist 4 99.96 Very High Very High Very High
guanethidine 1 96.24 Very High Very High Very High
Catecholamine 2 93.60 High High
antagonist 4 87.20 High High
Intracerebroventricular 4 84.80 Quite High
beta blocker 1 76.28 Quite High
anesthesia 1 74.08 Quite High
Central nervous system 2 30.60 Quite Low
Disease Link Frequency Relevance Heat
Stress 8 97.76 Very High Very High Very High
Ocular Hypertension 6 95.60 Very High Very High Very High
Hypertension 2 75.00 Quite High
Glaucoma 2 75.00 Quite High
Hypotension 1 47.40 Quite Low
Mydriatic 1 41.04 Quite Low
Cataract 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, selective beta2 adrenergic receptor blockade did not affect MCFP responses to BMI.
Negative_regulation (blockade) of beta2 adrenergic receptor
1) Confidence 0.24 Published 2006 Journal Brain Res. Section Abstract Doc Link 16473331 Disease Relevance 0 Pain Relevance 0.17
These results indicate that the increased renal sympathetic nerve activity and antinatriuresis resulting from environmental stress in conscious SHR can be prevented by pharmacological stimulation of central alpha 2-adrenergic receptors or by blockade of central beta 2-adrenergic receptors.
Negative_regulation (blockade) of beta 2-adrenergic in nerve associated with stress
2) Confidence 0.22 Published 1986 Journal Hypertension Section Abstract Doc Link 3002980 Disease Relevance 0.48 Pain Relevance 0.34
Apraclonidine hydrochloride is a derivative of clonidine hydrochloride, an alpha 2-adrenergic agonist.
Negative_regulation (derivative) of 2-adrenergic associated with agonist and clonidine
3) Confidence 0.00 Published 1991 Journal Drugs Section Abstract Doc Link 1711957 Disease Relevance 0.28 Pain Relevance 0.35

General Comments

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