INT149788

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.41
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Reln) extracellular space (Reln) extracellular region (Reln)
cell adhesion (Reln) proteinaceous extracellular matrix (Reln) cytoplasm (Reln)
Anatomy Link Frequency
neuronal 2
radial 1
Reln (Mus musculus)
Pain Link Frequency Relevance Heat
Lasting pain 1 99.48 Very High Very High Very High
Pain 6 96.56 Very High Very High Very High
Dorsal horn 3 91.92 High High
nMDA receptor 5 85.28 High High
Acute pain 1 80.88 Quite High
gABA 6 39.64 Quite Low
nociceptor 2 25.00 Low Low
long-term potentiation 12 5.00 Very Low Very Low Very Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 5 100.00 Very High Very High Very High
Pain 5 99.48 Very High Very High Very High
Disease 46 99.00 Very High Very High Very High
Injury 6 97.80 Very High Very High Very High
Alzheimer's Dementia 13 82.64 Quite High
Amyloid Plaque 6 77.12 Quite High
Nociception 1 75.00 Quite High
Adhesions 6 38.80 Quite Low
Disorder Of Lipid Metabolism 9 38.56 Quite Low
Dementia 2 35.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that the Reelin-Dab1 pathway differentially contributes to acute and persistent pain, and that the plasticity associated with the Reelin-Apoer 2-exon 19 pathway is distinct from that which contributes to injury-induced enhancement of 'pain' processing.
Reelin-Apoer 2-exon Binding (associated) of associated with pain, lasting pain and injury
1) Confidence 0.37 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279306 Disease Relevance 0.71 Pain Relevance 0.56
One set are proteins that are associated with Alzheimer’s disease, including myelin basic protein, 14-3-3 protein, syntaxin binding protein munc18, transketolase, heat shock protein HSP70, reelin, and calcium/calmodulin kinase II (Table 1).
reelin Binding (syntaxin binding protein munc18) of associated with shock and disease
2) Confidence 0.36 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.70 Pain Relevance 0
Soluble ApoER2 can effectively block Reelin binding to both ApoER2 and VLDLR and subsequent Reelin-dependent signaling in primary neuronal cells.
Reelin Binding (binding) of in neuronal
3) Confidence 0.16 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.04
These studies, as well as our observations, clearly indicate that reelin by its duel function on radial glia and neuronal migration is fundamental to the development of 6-layered lissencephalic as well as gyrencephalic cortices.


reelin Binding (migration) of in neuronal
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
To test whether exogenous reelin also affects BLBP expression, the number of processes expressing both radial glial markers, vimentin and BLBP, or only one these markers, was quantified (see Table 2).
reelin Spec (whether) Binding (exogenous) of in radial
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

General Comments

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