INT149791

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 0.38
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lrp8, Reln) extracellular region (Lrp8, Reln) peptidase activity (Reln)
cell adhesion (Reln) proteinaceous extracellular matrix (Reln) plasma membrane (Lrp8)
Anatomy Link Frequency
neuronal 4
Lrp8 (Mus musculus)
Reln (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 4 99.72 Very High Very High Very High
nMDA receptor 10 85.28 High High
Dorsal horn 3 70.96 Quite High
gABA 12 39.36 Quite Low
cerebral cortex 20 28.28 Quite Low
Pain 6 25.00 Low Low
nociceptor 2 25.00 Low Low
Lasting pain 1 25.00 Low Low
Acute pain 1 25.00 Low Low
long-term potentiation 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 15 100.00 Very High Very High Very High
Nociception 1 75.00 Quite High
Malformations Of Cortical Development 28 46.08 Quite Low
Adhesions 12 40.24 Quite Low
Injury 8 25.00 Low Low
Pain 5 25.00 Low Low
Neurodegenerative Disease 26 14.60 Low Low
Disease 66 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 40 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reeler gene encodes Reelin, a secreted glycoprotein that binds to the very-low-density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (Apoer 2), and induces Src- and Fyn-mediated tyrosine phosphorylation of the intracellular adaptor protein Disabled-1 (Dab1).
apolipoprotein E receptor 2 Binding (binds) of Reelin associated with disorder of lipid metabolism
1) Confidence 0.36 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279306 Disease Relevance 0.17 Pain Relevance 0.04
Soluble ApoER2 can effectively block Reelin binding to both ApoER2 and VLDLR and subsequent Reelin-dependent signaling in primary neuronal cells.
ApoER2 Binding (binding) of Reelin in neuronal
2) Confidence 0.13 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.04
Soluble ApoER2 can effectively block Reelin binding to both ApoER2 and VLDLR and subsequent Reelin-dependent signaling in primary neuronal cells.
ApoER2 Binding (binding) of Reelin in neuronal
3) Confidence 0.13 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1635701 Disease Relevance 0 Pain Relevance 0.04
Reelin signaling requires binding to receptors of the lipoprotein family, very low density-lipoprotein (VLDLR) and the apolipoprotein E receptor (ApoER2), which triggers tyrosine phosphorylation of the cytoplasmic adapter protein Disabled-1 (Dab1) [34], [35], [36].
ApoER2 Binding (binding) of Reelin associated with disorder of lipid metabolism
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.10 Pain Relevance 0.05
Reelin signaling requires binding to receptors of the lipoprotein family, very low density-lipoprotein (VLDLR) and the apolipoprotein E receptor (ApoER2), which triggers tyrosine phosphorylation of the cytoplasmic adapter protein Disabled-1 (Dab1) [34], [35], [36].
apolipoprotein E receptor Binding (binding) of Reelin associated with disorder of lipid metabolism
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.10 Pain Relevance 0.05
Jossin et al. [56] demonstrate that the central fragment of reelin binds to ApoER2 and VLDLR but does not bind to cadherin-related neuronal receptors.
ApoER2 Binding (binds) of reelin in neuronal
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Jossin et al. [56] demonstrate that the central fragment of reelin binds to ApoER2 and VLDLR but does not bind to cadherin-related neuronal receptors.
ApoER2 Neg (not) Binding (bind) of reelin in neuronal
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

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