INT1498

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Context Info
Confidence 0.75
First Reported 1978
Last Reported 2010
Negated 11
Speculated 12
Reported most in Abstract
Documents 521
Total Number 533
Disease Relevance 220.84
Pain Relevance 81.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
plasma 40
pituitary 29
thyroid 15
blood 11
anterior pituitary 10
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 4330 100.00 Very High Very High Very High
Clonidine 612 100.00 Very High Very High Very High
agonist 607 100.00 Very High Very High Very High
antagonist 413 100.00 Very High Very High Very High
Pain 271 100.00 Very High Very High Very High
cytokine 160 100.00 Very High Very High Very High
narcan 65 100.00 Very High Very High Very High
withdrawal 262 99.92 Very High Very High Very High
Serotonin 130 99.86 Very High Very High Very High
headache 240 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3635 100.00 Very High Very High Very High
Aging 2732 100.00 Very High Very High Very High
Insulin Resistance 405 100.00 Very High Very High Very High
Pain 212 100.00 Very High Very High Very High
Hypoglycemia 163 100.00 Very High Very High Very High
Growth Problems 139 100.00 Very High Very High Very High
Coagulation Disorder 3 100.00 Very High Very High Very High
Targeted Disruption 827 99.98 Very High Very High Very High
Pituitary Cancer 436 99.96 Very High Very High Very High
Growth Hormone Deficiency 117 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Female transgenic mice expressing the bovine (b) growth hormone (GH) gene exhibit reduced fertility, and GH-deficient dwarf mice are sterile.
Gene_expression (expressing) of growth hormone associated with targeted disruption
1) Confidence 0.75 Published 1996 Journal Biol. Reprod. Section Abstract Doc Link 8722619 Disease Relevance 0.24 Pain Relevance 0
Plasma growth hormone (GH) levels at the end of insulin and clonidine tests were considered for classification of children into 3 categories according to severity of GH deficit: total deficit of GH (TD), partial deficit (PD, and familiar short stature (FSS; no deficit of GH).
Gene_expression (levels) of GH in Plasma associated with growth problems and clonidine
2) Confidence 0.72 Published 2002 Journal Metab. Clin. Exp. Section Abstract Doc Link 11782864 Disease Relevance 0.56 Pain Relevance 0.10
As a step in the evaluation of the role of growth hormone (GH) in mammary tumorigenesis, the effects of neonatal treatment with monosodium glutamate (MSG) on normal and neoplastic mammary growth, plasma levels of GH and prolactin (PRL) and the pattern of estrous cycles were determined in SHN virgin mice.
Gene_expression (role) of GH in plasma associated with glutamate
3) Confidence 0.67 Published 1985 Journal Eur J Cancer Clin Oncol Section Abstract Doc Link 3830732 Disease Relevance 0.22 Pain Relevance 0.31
As a step in the evaluation of the role of growth hormone (GH) in mammary tumorigenesis, the effects of neonatal treatment with monosodium glutamate (MSG) on normal and neoplastic mammary growth, plasma levels of GH and prolactin (PRL) and the pattern of estrous cycles were determined in SHN virgin mice.
Gene_expression (role) of growth hormone in plasma associated with glutamate
4) Confidence 0.67 Published 1985 Journal Eur J Cancer Clin Oncol Section Abstract Doc Link 3830732 Disease Relevance 0.22 Pain Relevance 0.31
In conclusion, pain during GH injection can be significantly diminished by automatic needle insertion, which may improve compliance in long-term GH treatment.
Gene_expression (injection) of GH associated with pain
5) Confidence 0.67 Published 1995 Journal Acta Paediatr. Section Abstract Doc Link 7780258 Disease Relevance 0.57 Pain Relevance 0.66
RESULTS: All six patients treated with fluoxetine and two of the six patients given placebo demonstrated an increase in their dexamethasone-induced GH responses.
Gene_expression (responses) of GH
6) Confidence 0.67 Published 1995 Journal Am J Psychiatry Section Body Doc Link 7694914 Disease Relevance 0 Pain Relevance 0
No difference was observed between GH response in depressed and demented patients.
Gene_expression (response) of GH
7) Confidence 0.67 Published 1989 Journal Psychiatry Res Section Abstract Doc Link 2710869 Disease Relevance 0.52 Pain Relevance 0.26
Non-compliance in children receiving growth hormone (GH) treatment is often caused by pain on injection and difficulties in administration of GH.
Gene_expression (receiving) of GH associated with pain
8) Confidence 0.67 Published 1995 Journal Acta Paediatr. Section Abstract Doc Link 7780258 Disease Relevance 0.46 Pain Relevance 0.46
In contrast to other studies, this study shows no sustained increases in GH production or in improved growth velocity with long-term administration of a single daily dose of clonidine.
Gene_expression (production) of GH associated with clonidine
9) Confidence 0.66 Published 1988 Journal Lancet Section Abstract Doc Link 2902319 Disease Relevance 0.07 Pain Relevance 0.59
Headaches can also occur as premenstrual migraine or as water retention due to glucocorticoid or Growth Hormone (GH) overdosage.
Gene_expression (overdosage) of Growth Hormone associated with pressure and volume under development, migraine and headache
10) Confidence 0.66 Published 2004 Journal Pediatr Endocrinol Rev Section Abstract Doc Link 16437026 Disease Relevance 0.74 Pain Relevance 0.45
Headaches can also occur as premenstrual migraine or as water retention due to glucocorticoid or Growth Hormone (GH) overdosage.
Gene_expression (overdosage) of GH associated with pressure and volume under development, migraine and headache
11) Confidence 0.66 Published 2004 Journal Pediatr Endocrinol Rev Section Abstract Doc Link 16437026 Disease Relevance 0.73 Pain Relevance 0.45
Because doses and scheduling of GH administration have changed since the introduction of recombinant GH, higher doses and increased frequency of administration may be contributing to the development of IH in some patients.
Gene_expression (introduction) of GH associated with cva
12) Confidence 0.66 Published 1995 Journal J. Pediatr. Section Abstract Doc Link 7776116 Disease Relevance 1.04 Pain Relevance 0.33
Because doses and scheduling of GH administration have changed since the introduction of recombinant GH, higher doses and increased frequency of administration may be contributing to the development of IH in some patients.
Gene_expression (introduction) of GH associated with cva
13) Confidence 0.66 Published 1995 Journal J. Pediatr. Section Abstract Doc Link 7776116 Disease Relevance 1.05 Pain Relevance 0.34
Conventional super-voltage irradiation by 5-10 yr produces the same fall in plasma GH as all other forms of treatment for acromegaly, including transphenoidal microsurgery.
Gene_expression (produces) of GH in plasma associated with acromegaly
14) Confidence 0.65 Published 1979 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 447799 Disease Relevance 0.63 Pain Relevance 0.08
Growth hormone (GH) is lipolytic in ruminants; therefore, pulsatile GH secretion was measured in three young reindeer (Rangifer tarandus tarandus) bulls during the natural period of weight loss during rut.
Gene_expression (lipolytic) of Growth hormone associated with appetite loss
15) Confidence 0.64 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1563616 Disease Relevance 0.36 Pain Relevance 0
Growth hormone (GH) is lipolytic in ruminants; therefore, pulsatile GH secretion was measured in three young reindeer (Rangifer tarandus tarandus) bulls during the natural period of weight loss during rut.
Gene_expression (lipolytic) of GH associated with appetite loss
16) Confidence 0.64 Published 1992 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 1563616 Disease Relevance 0.36 Pain Relevance 0
Kurahashi et al. found that patients treated by ESWL alone had a significantly higher score for GH perception, whereas no significant differences were detected in the remaining seven scores [17].
Gene_expression (perception) of GH
17) Confidence 0.64 Published 2010 Journal Health Qual Life Outcomes Section Body Doc Link PMC2974666 Disease Relevance 0.59 Pain Relevance 0.22
In conclusion, octreotide is effective in the treatment of acromegaly; however, it is better used in patients who have serum GH levels < 20 mU/L, or after a trans-sphenoidal adenomectomy, and may be combined with bromocriptine to treat the patient.
Gene_expression (levels) of GH associated with acromegaly
18) Confidence 0.64 Published 1992 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 1358345 Disease Relevance 0.44 Pain Relevance 0.18
We performed a double-blind, placebo-controlled crossover study of nightly oral clonidine therapy (0.1 mg/m2) in 10 short, slowly growing, non-GH-deficient (stimulated GH level > 15 micrograms/L) prepubertal boys (range, 6.1 to 12.2 years; mean height standard deviation score, -2.3 +/- 0.4).
Gene_expression (deficient) of GH associated with clonidine
19) Confidence 0.63 Published 1993 Journal J. Pediatr. Section Abstract Doc Link 8419612 Disease Relevance 0.16 Pain Relevance 0.53
We performed a double-blind, placebo-controlled crossover study of nightly oral clonidine therapy (0.1 mg/m2) in 10 short, slowly growing, non-GH-deficient (stimulated GH level > 15 micrograms/L) prepubertal boys (range, 6.1 to 12.2 years; mean height standard deviation score, -2.3 +/- 0.4).
Gene_expression (deficient) of GH associated with clonidine
20) Confidence 0.63 Published 1993 Journal J. Pediatr. Section Abstract Doc Link 8419612 Disease Relevance 0.16 Pain Relevance 0.53

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