INT149815

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 0.87
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (Clock) DNA binding (Clock) cytoplasm (Clock)
signal transducer activity (Clock) signal transduction (Clock) chromosome (Clock)
Anatomy Link Frequency
retinas 2
reproductive organs 2
SCN 2
limb 2
Clock (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 89 99.76 Very High Very High Very High
tetrodotoxin 17 95.84 Very High Very High Very High
gABA 129 93.68 High High
monoamine 16 93.36 High High
Neurotransmitter 26 81.04 Quite High
agonist 53 78.60 Quite High
Action potential 13 77.28 Quite High
depression 77 76.88 Quite High
antidepressant 42 49.52 Quite Low
Ventral tegmentum 4 49.40 Quite Low
Disease Link Frequency Relevance Heat
Disease 36 84.64 Quite High
Breast Cancer 34 80.96 Quite High
Depression 85 76.88 Quite High
Endometriosis (extended) 8 73.16 Quite High
Repression 12 69.52 Quite High
Targeted Disruption 24 64.40 Quite High
Manic Depressive Disorder 7 56.72 Quite High
Sleep Disorders 62 50.00 Quite Low
Ganglion Cysts 26 46.72 Quite Low
Affective Disorder 23 38.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, the expression of circadian genes such as Clock, Per1, and Bmal1 is stimulated when dopamine D1 receptor is activated, and suppressed when dopamine D2 receptor is activated in the limbic area [119].
Positive_regulation (stimulated) of Gene_expression (expression) of Clock associated with dopamine
1) Confidence 0.46 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.36 Pain Relevance 0.41
Chromatin immunoprecipitation (ChIP) of CLOCK in NIH3T3 cells indicates that CLOCK interacts with this E-box-rich region [25], suggesting that CLOCK might activate PPAR?
Positive_regulation (indicates) of Gene_expression (immunoprecipitation) of CLOCK
2) Confidence 0.46 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0
The acetylated Bmal1/CLOCK heterodimer then binds to the E-box (5?
Positive_regulation (acetylated) of Gene_expression (heterodimer) of CLOCK
3) Confidence 0.46 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.07 Pain Relevance 0
Circadian clock proteins control PPARs expression by at least two mechanisms: (1) activation of PPAR?
Positive_regulation (activation) of Gene_expression (proteins) of clock
4) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.04
In the present study, we developed a retinal explant culture protocol that enables the assay of circadian clock gene expression rhythms in real time from isolated, intact mPer2Luc mouse retinas.
Positive_regulation (enables) of Gene_expression (expression) of clock in retinas
5) Confidence 0.36 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.34
This perturbation in the steroid hormone signal can lead to a change in the expression of circadian clock genes both within the SCN and in peripheral tissues including female reproductive organs.
Positive_regulation (lead) of Gene_expression (expression) of clock in reproductive organs
6) Confidence 0.26 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.31 Pain Relevance 0
Transfecting these cells with an altered CLOCK protein (Clock?
Positive_regulation (Transfecting) of Gene_expression (Transfecting) of Clock
7) Confidence 0.26 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.13 Pain Relevance 0
The positive limb of the mammalian clock machinery is comprised of CLOCK and BMAL1, which are transcription factors that heterodimerize through the PAS domain and induce the expression of clock-controlled genes by binding to their promoters at E-boxes.
Positive_regulation (induce) of Gene_expression (expression) of clock-controlled in limb
8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0
These findings indicate that input through Na+-channel-dependent electrophysiological activity is not necessary for the expression of the circadian rhythms of clock and clock-associated genes, but necessary for full expression of the circadian rhythms of BDNF and PK2 in the SCN.
Neg (not) Positive_regulation (necessary) of Gene_expression (expression) of clock-associated in SCN
9) Confidence 0.03 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279366 Disease Relevance 0 Pain Relevance 0.65

General Comments

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