INT149816

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 31
Disease Relevance 18.99
Pain Relevance 15.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Prok2) extracellular region (Prok2)
Anatomy Link Frequency
neurons 3
SCN 3
macrophages 2
myeloid cells 2
spleen 2
Prok2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 446 99.84 Very High Very High Very High
dorsal root ganglion 364 99.64 Very High Very High Very High
Pain 174 99.60 Very High Very High Very High
tetrodotoxin 24 99.24 Very High Very High Very High
Inflammatory response 126 99.20 Very High Very High Very High
qutenza 434 98.88 Very High Very High Very High
cytokine 500 98.68 Very High Very High Very High
IPN 95 95.88 Very High Very High Very High
Hyperalgesia 70 90.96 High High
substance P 14 89.68 High High
Disease Link Frequency Relevance Heat
Crystal Associated Disease 186 100.00 Very High Very High Very High
INFLAMMATION 544 99.84 Very High Very High Very High
Ganglion Cysts 364 99.64 Very High Very High Very High
Pain 174 99.60 Very High Very High Very High
Nociception 434 99.00 Very High Very High Very High
Injury 39 98.88 Very High Very High Very High
Pressure And Volume Under Development 28 98.60 Very High Very High Very High
Cancer 20 97.46 Very High Very High Very High
Neurogenic Inflammation 28 96.76 Very High Very High Very High
Inflammatory Pain 95 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently it has been demonstrated that PK2 is expressed in inflammatory cells and PK2 expression is strongly increased in inflammatory paw skin of mice [9,14].
Gene_expression (expressed) of PK2 in skin associated with inflammation
1) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.24 Pain Relevance 0.76
In this study, we showed that PK2 was also expressed in many DRG neurons.
Gene_expression (expressed) of PK2 in neurons associated with dorsal root ganglion
2) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.18 Pain Relevance 0.67
Two receptors for PK2, PKR1 and PKR2, are expressed in some DRG neurons, implying that PK2 may directly activate these PKRs-expressing neurons.
Gene_expression (expressed) of PK2 in neurons associated with dorsal root ganglion
3) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.63 Pain Relevance 1.60
Recently it has been demonstrated that PK2 is expressed in inflammatory cells and PK2 expression is strongly increased in inflammatory paw skin of mice [9,14].
Gene_expression (expression) of PK2 in skin associated with inflammation
4) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.19 Pain Relevance 0.71
Interestingly, we also observed the expression of PK2 mRNA in some small DRG cells, some of which were TRPV1-positive (Fig. 3G–I).
Gene_expression (expression) of PK2 mRNA associated with dorsal root ganglion
5) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.98 Pain Relevance 0.67
Bv8 is highly expressed in mouse and human immune cells, and has been reported in mouse and human monocytes, macrophages, granulocytes, spleen and bone marrow [7,18,19].
Gene_expression (expressed) of Bv8 in spleen
6) Confidence 0.70 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.19 Pain Relevance 0.17
It has very recently been shown that the implantation of tumour cells in mice upregulates Bv8 in serum, bone marrow and spleen myeloid cells, and that G-CSF is a positive major regulator of Bv8 expression [5].
Gene_expression (expression) of Bv8 in myeloid cells associated with cancer
7) Confidence 0.70 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.44 Pain Relevance 0.32
Nociceptive sensitization to thermal stimuli by intraplantar injection of PK2
Gene_expression (injection) of PK2 associated with nociception
8) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.09 Pain Relevance 0.80
Digoxigenin (DIG)-labeled PK2, PKR1 and PKR2 riboprobes and their sense control riboprobes were made using DIG RNA labeling mix from Roche.
Gene_expression (riboprobes) of PK2
9) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.07 Pain Relevance 0.03
Intriguingly, where does the PK2 come from at the site of tissue injury?
Gene_expression (come) of PK2 associated with injury
10) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.18 Pain Relevance 0.75
When 300 nM PK2 was applied, [Ca2+]i increased in about 65% of acutely dissociated DRG neurons (38/59).
Gene_expression (applied) of PK2 in neurons associated with dorsal root ganglion
11) Confidence 0.67 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.26 Pain Relevance 0.88
A TTX-sensitive local circuit is involved in the expression of PK2 and BDNF circadian rhythms in the mouse suprachiasmatic nucleus.
Gene_expression (expression) of PK2 in suprachiasmatic nucleus
12) Confidence 0.67 Published 2008 Journal Eur. J. Neurosci. Section Title Doc Link 18279366 Disease Relevance 0 Pain Relevance 0.53
A TTX-sensitive circuit is involved in the expression of BDNF and PK2 circadian rhythms in the mouse SCN.
Gene_expression (expression) of PK2 in SCN associated with tetrodotoxin
13) Confidence 0.67 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279366 Disease Relevance 0 Pain Relevance 0.60
These findings indicate that input through Na+-channel-dependent electrophysiological activity is not necessary for the expression of the circadian rhythms of clock and clock-associated genes, but necessary for full expression of the circadian rhythms of BDNF and PK2 in the SCN.
Gene_expression (expression) of PK2 in SCN
14) Confidence 0.67 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279366 Disease Relevance 0 Pain Relevance 0.63
The 4-hour interval between Bv8 administration and spleen harvesting was chosen on the basis of previously published data concerning the pharmacodynamics and pharmacokinetics of Bv8, which show that it modulates a number of biological functions at this time [10,29]
Gene_expression (administration) of Bv8 in spleen
15) Confidence 0.61 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.18 Pain Relevance 0.17
were significantly increased by the administration of Bv8, whereas the production of IL-2 and IFN-?
Gene_expression (administration) of Bv8
16) Confidence 0.61 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.07 Pain Relevance 0.18
As PK2 mRNA is expressed in inflammatory cells, the capsaicin-induced inflammatory response was examined to determine whether the altered behavioral response to capsaicin in PK2-/- mice was related to the difference in inflammatory response.
Gene_expression (expressed) of PK2 mRNA associated with inflammatory response, qutenza and inflammation
17) Confidence 0.60 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.85 Pain Relevance 1.08
As PK2 is also expressed in inflammatory cells [9,14], it was intriguing to find out whether the attenuated nociceptive response to capsaicin in PK2-/- mice was due to altered inflammation.
Gene_expression (expressed) of PK2 associated with nociception, qutenza and inflammation
18) Confidence 0.60 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.64 Pain Relevance 1.58
PK2 is highly expressed in peripheral blood cells, notably in monocytes, neutrophils, and dendritic cells.
Gene_expression (expressed) of PK2 in neutrophils
19) Confidence 0.60 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 0.93 Pain Relevance 0.72
Significantly lower amounts of IL-4 were also found in the Con-A-stimulated cultures of splenocytes harvested from the Bv8-treated animals (Fig. 5, panel C).


Gene_expression (animals) of Bv8-treated
20) Confidence 0.53 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.11 Pain Relevance 0.11

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