INT149818

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 81
Total Number 82
Disease Relevance 14.15
Pain Relevance 10.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (Clock) DNA binding (Clock) cytoplasm (Clock)
signal transducer activity (Clock) signal transduction (Clock) chromosome (Clock)
Anatomy Link Frequency
liver 6
retinas 4
neurons 4
autonomic 3
SCN 3
Clock (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 169 99.84 Very High Very High Very High
endometriosis 60 99.56 Very High Very High Very High
cocaine 13 99.50 Very High Very High Very High
Morphine 288 99.46 Very High Very High Very High
Dopamine 1034 98.52 Very High Very High Very High
addiction 102 97.80 Very High Very High Very High
drug abuse 9 97.58 Very High Very High Very High
withdrawal 223 97.20 Very High Very High Very High
gABA 1678 96.68 Very High Very High Very High
Neurotransmitter 333 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 237 99.84 Very High Very High Very High
Breast Cancer 340 99.80 Very High Very High Very High
Endometriosis (extended) 83 99.56 Very High Very High Very High
Sleep Disorders 666 99.36 Very High Very High Very High
Shock 92 99.12 Very High Very High Very High
Morphine Dependence 36 98.16 Very High Very High Very High
Drug Dependence 27 97.58 Very High Very High Very High
Targeted Disruption 247 96.84 Very High Very High Very High
Affective Disorder 109 95.52 Very High Very High Very High
Aging 53 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
positively regulates the expression of clock components, including CLOCK, Bmal1, and Rev-erb?
Gene_expression (expression) of CLOCK
1) Confidence 0.70 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.26 Pain Relevance 0
Experiments in mice revealed distinct expression patterns of clock genes in the liver and hepatic lipid homeostasis differences between males and females [50].
Gene_expression (expression) of clock in liver
2) Confidence 0.61 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.39 Pain Relevance 0
Chromatin immunoprecipitation (ChIP) of CLOCK in NIH3T3 cells indicates that CLOCK interacts with this E-box-rich region [25], suggesting that CLOCK might activate PPAR?
Gene_expression (immunoprecipitation) of CLOCK
3) Confidence 0.61 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0
The acetylated Bmal1/CLOCK heterodimer then binds to the E-box (5?
Gene_expression (heterodimer) of CLOCK
4) Confidence 0.61 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.07 Pain Relevance 0
Thus, there is a strong correlation of core clock gene expression within GABAergic retinal neurons, suggesting a molecular basis for circadian regulation of this neurotransmitter.
Gene_expression (expression) of clock in neurons associated with neurotransmitter and gabaergic
5) Confidence 0.59 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.67
The full complement of core clock genes is expressed in GABAergic horizontal cells and dopaminergic amacrine cells, which also express GABA [43].
Gene_expression (expressed) of clock in horizontal cells associated with gaba and gabaergic
6) Confidence 0.59 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.66
Multiple approaches, including in situ hybridization, immunocytochemistry, and single-cell reverse-transcriptase PCR (RT-PCR), have established that the Per2 clock gene is expressed, with varying levels and frequencies, in all the major subtypes of retinal neurons [13,43,48].
Gene_expression (expressed) of clock in neurons
7) Confidence 0.59 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.09 Pain Relevance 0.08
Cell-type–specific mapping of coordinate expression of the core circadian clock genes has demonstrated that significant proportions of horizontal, rod bipolar, and dopaminergic amacrine neurons of the inner nuclear layer express all six core clock genes and thus are candidate cell types for self-sustained circadian rhythms generation [43].
Gene_expression (express) of clock in amacrine neurons
8) Confidence 0.59 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.22 Pain Relevance 0.07
Cell-type–specific mapping of coordinate expression of the core circadian clock genes has demonstrated that significant proportions of horizontal, rod bipolar, and dopaminergic amacrine neurons of the inner nuclear layer express all six core clock genes and thus are candidate cell types for self-sustained circadian rhythms generation [43].
Gene_expression (expression) of clock in amacrine neurons
9) Confidence 0.59 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.15 Pain Relevance 0.08
A Student's t-test was applied to compare clock gene expression levels between treatment and vehicle.


Gene_expression (expression) of clock
10) Confidence 0.59 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.08
To determine whether melatonin signaling is required to maintain retinal rhythmicity in clock gene expression, we assayed luminescence rhythms from retinal explants derived from mPer2Luc C57BL/6J mice, in which melatonin synthesis is genetically blunted [19,45].
Gene_expression (expression) of clock
11) Confidence 0.59 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.25 Pain Relevance 0.20
Circadian clocks in mammalian tissues generate molecular circadian rhythms through coupled transcription/translation feedback loops in which the positive gene elements Clock and Bmal1 interact with the negative gene elements Period (Per) 1 and 2, and Cryptochrome (Cry) 1 and 2, and in which casein kinases, CKI?
Gene_expression (positive) of Clock
12) Confidence 0.59 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.26
Dissociation of behavioral FAA rhythms and peripheral clock gene expression is not uncommon [14], [15].
Gene_expression (expression) of clock
13) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734168 Disease Relevance 0.08 Pain Relevance 0.08
Dissociation of behavioral FAA rhythms and peripheral clock gene expression has been reported [14], [15].
Gene_expression (expression) of clock
14) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734168 Disease Relevance 0 Pain Relevance 0
Consequently, the daily SFR rhythm reflects the intrinsic periodicity of clock gene expression in the SCN, and mutations alter SFR rhythms in individual SCN neurons in a way that reflects the primary pacemaker alteration and behavioral outputs.
Gene_expression (expression) of clock in neurons
15) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2586654 Disease Relevance 0 Pain Relevance 0.08
In wild-type mice, clock genes (Bmal1, Per1, Per3, and Rev-erb?)
Gene_expression (genes) of clock
16) Confidence 0.53 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.07
-null mice, although other clock genes can still be reset, Bmal1 was irresponsive to daytime feeding triggered by circadian reprogramming, suggesting that Bmal1 expression is controlled by PPAR?
Gene_expression (reset) of clock
17) Confidence 0.53 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.10
positively regulates the expression of clock components, including CLOCK, Bmal1, and Rev-erb?
Gene_expression (components) of clock
18) Confidence 0.53 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.25 Pain Relevance 0
positively regulates the expression of clock components, including CLOCK, Bmal1, and Rev-erb?
Gene_expression (expression) of clock
19) Confidence 0.53 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.26 Pain Relevance 0
Circadian clock proteins control PPARs expression by at least two mechanisms: (1) activation of PPAR?
Gene_expression (proteins) of clock
20) Confidence 0.53 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox