INT149821

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.46
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr1d1) DNA binding (Nr1d1)
Anatomy Link Frequency
saliva 1
salivary gland 1
Nr1d1 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 8 98.28 Very High Very High Very High
Nerve growth factor 75 94.16 High High
Inflammation 33 83.44 Quite High
chemokine 6 39.28 Quite Low
cytokine 6 32.60 Quite Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Nicotine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
methadone 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 54 99.40 Very High Very High Very High
Melanoma 153 98.84 Very High Very High Very High
Salivary Gland Disease 54 95.80 Very High Very High Very High
Cancer 201 94.84 High High
Aids-related Complex 74 93.28 High High
Lung Cancer 61 83.72 Quite High
INFLAMMATION 32 83.44 Quite High
Disease 101 77.88 Quite High
Mouth Cancer 12 75.00 Quite High
Reticuloendotheliosis 1 24.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most notably, we found a consistent increased expression of NR1D1 in both mouse strains at 4 and 16 weeks post-exposure.
Gene_expression (expression) of NR1D1 associated with sprains and strains
1) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.09 Pain Relevance 0.13
After overlapping the associated genes of each TF, it can be seen that the altered activities of the three TFs (RunX1, MLXIPL and TRIM30) can be potentially responsible for 83% of the up-regulated mRNAs in saliva (Fig. 4G) whereas the collective altered activities of Egr1, Tbx1 and Nr1d1 can potentially account for 63% of the down-regulated expression of salivary mRNAs (Fig. 4H).


Gene_expression (expression) of Nr1d1 in saliva
2) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0.93 Pain Relevance 0.19
Furthermore, we identified that the expression of two groups of significantly altered transcription factors (TFs) Runx1, Mlxipl, Trim30 and Egr1, Tbx1, Nr1d1 in salivary gland tissue of melanoma-bearing mice can potentially be responsible for 82.6% of the up-regulated gene expression and 62.5% of the down-regulated gene expression, respectively, in the saliva of melanoma-bearing mice.
Gene_expression (expression) of Nr1d1 in salivary gland associated with melanoma
3) Confidence 0.46 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2691577 Disease Relevance 1.57 Pain Relevance 0.08
The relative fold changes of TF expression such as Egr1 and Nr1d1 are different between mRNA levels and protein levels, which may reflect translational modification or proteasomal degradation [25].
Gene_expression (expression) of Nr1d1
4) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0.87 Pain Relevance 0.07
The circadian rhythms in the expression of clock genes, Per1, Per2, Bmal1 and Cry1, and of clock-associated genes, Dec1, Dec2, Rev-erbalpha, Rev-erbbeta and DBP, were not affected by TTX treatment.
Gene_expression (expression) of Rev-erbalpha associated with tetrodotoxin
5) Confidence 0.38 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279366 Disease Relevance 0 Pain Relevance 0.69

General Comments

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