INT149867

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TP53INP2)
Anatomy Link Frequency
fibroblasts 3
skin 2
keratinocytes 1
TP53INP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 16 50.00 Quite Low
Enkephalin 1 50.00 Quite Low
pruritus 4 5.00 Very Low Very Low Very Low
painful pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Keloid Scars 12 70.72 Quite High
Colon Cancer 2 54.72 Quite High
Metastasis 2 53.84 Quite High
Nociception 4 5.00 Very Low Very Low Very Low
Pruritus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Our results demonstrate that expression of three types of ORs, MOR, DOR and KOR, was markedly upregulated in human hypertrophic scars, suggesting a possible link between upregulated ORs and local cacaesthesia in hypertrophic scars.


Positive_regulation (upregulated) of Gene_expression (expression) of DOR
1) Confidence 0.41 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.06 Pain Relevance 0
Real-time PCR indicated that the expression of MOR, DOR and KOR in hypertrophic scars was enhanced in comparison with normal skin.
Positive_regulation (enhanced) of Gene_expression (expression) of DOR in skin
2) Confidence 0.41 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.07 Pain Relevance 0
Consistent with the results from skin biopsy, we observed enhanced expression of MOR, DOR and KOR in the cultured keratinocytes and fibroblasts derived from hypertrophic scars in comparison with those derived from normal skin.
Positive_regulation (enhanced) of Gene_expression (expression) of DOR in fibroblasts
3) Confidence 0.41 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.06 Pain Relevance 0
Nitric oxide was found to induce DOR expression in CRC cells.
Positive_regulation (induce) of Gene_expression (expression) of DOR
4) Confidence 0.20 Published 2010 Journal Gut Section Body Doc Link 19828468 Disease Relevance 0.11 Pain Relevance 0
Consistent with the results from skin biopsy, we observed enhanced expression of MOR, DOR and KOR in the cultured keratinocytes and fibroblasts derived from hypertrophic scars in comparison with those derived from normal skin.
Positive_regulation (enhanced) of in keratinocytes Gene_expression (expression) of DOR in fibroblasts
5) Confidence 0.14 Published 2008 Journal Br. J. Dermatol. Section Body Doc Link 18284397 Disease Relevance 0.06 Pain Relevance 0

General Comments

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