INT149889

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.58
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mmp14)
Anatomy Link Frequency
plasma 4
Mmp14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 22 82.76 Quite High
fibrosis 13 58.84 Quite High
Chronic pancreatitis 4 46.64 Quite Low
dexamethasone 9 22.48 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 36 99.52 Very High Very High Very High
Fibrosis 12 58.84 Quite High
Bronchopulmonary Dysplasia 61 50.00 Quite Low
Injury 5 49.80 Quite Low
Pancreatitis 4 46.64 Quite Low
Pulmonary Fibrosis 1 30.24 Quite Low
Disease 2 28.32 Quite Low
Hyperoxia 7 23.60 Low Low
Birth Weight 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although MMP16 is closely related to MMP14 in terms of its molecular structure and tissue expression pattern [10], [24], differences in the expression profiles suggest that MMP16 is not merely functionally redundant to MMP14.
Neg (not) Localization (redundant) of MMP14
1) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0 Pain Relevance 0
Unexpectedly, however, adenovirus-mediated Gli-1 overexpression blocked the Ihh enhancement of both MT1-MMP localization on the plasma membrane and PSC migration.
Localization (localization) of MT1-MMP in plasma associated with primary sclerosing cholangitis
2) Confidence 0.05 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.71 Pain Relevance 0.20
Unexpectedly, however, adenovirus-mediated Gli-1 overexpression blocked the Ihh enhancement of both MT1-MMP localization on the plasma membrane and PSC migration.
Localization (localization) of MT1-MMP in plasma associated with primary sclerosing cholangitis
3) Confidence 0.05 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.71 Pain Relevance 0.20
These data indicate that Ihh promotes PSC migration by enhancing MT1-MMP localization on the plasma membrane but is negatively regulated by Gli-1.
Localization (localization) of MT1-MMP in plasma associated with primary sclerosing cholangitis
4) Confidence 0.04 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.58 Pain Relevance 0.11
These data indicate that Ihh promotes PSC migration by enhancing MT1-MMP localization on the plasma membrane but is negatively regulated by Gli-1.
Localization (localization) of MT1-MMP in plasma associated with primary sclerosing cholangitis
5) Confidence 0.04 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.58 Pain Relevance 0.11

General Comments

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