INT149894

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.06
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ihh) embryo development (Ihh) molecular_function (Ihh)
cellular_component (Ihh) cytoplasm (Mmp14)
Anatomy Link Frequency
plasma 6
Ihh (Rattus norvegicus)
Mmp14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 9 83.72 Quite High
fibrosis 9 59.80 Quite High
Chronic pancreatitis 3 47.60 Quite Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 27 100.00 Very High Very High Very High
Fibrosis 9 59.80 Quite High
Injury 3 50.76 Quite High
Pancreatitis 3 47.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that Ihh promotes PSC migration by enhancing MT1-MMP localization on the plasma membrane but is negatively regulated by Gli-1.
Ihh Positive_regulation (enhancing) of Localization (localization) of MT1-MMP in plasma associated with primary sclerosing cholangitis
1) Confidence 0.04 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.65 Pain Relevance 0.13
Unexpectedly, however, adenovirus-mediated Gli-1 overexpression blocked the Ihh enhancement of both MT1-MMP localization on the plasma membrane and PSC migration.
Ihh Positive_regulation (enhancement) of Localization (localization) of MT1-MMP in plasma associated with primary sclerosing cholangitis
2) Confidence 0.03 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.77 Pain Relevance 0.20
These data indicate that Ihh promotes PSC migration by enhancing MT1-MMP localization on the plasma membrane but is negatively regulated by Gli-1.
Ihh Positive_regulation (enhancing) of Localization (localization) of MT1-MMP in plasma associated with primary sclerosing cholangitis
3) Confidence 0.03 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 18286538 Disease Relevance 0.65 Pain Relevance 0.13

General Comments

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