INT1499

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Context Info
Confidence 0.42
First Reported 1978
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 58
Total Number 59
Disease Relevance 25.17
Pain Relevance 7.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
thyroid 6
pituitary 6
growth plate 6
anterior pituitary 6
plasma 4
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 26 100.00 Very High Very High Very High
Arthritis 25 99.98 Very High Very High Very High
narcan 6 99.92 Very High Very High Very High
Pain 40 99.84 Very High Very High Very High
agonist 81 99.78 Very High Very High Very High
Somatostatin 467 99.70 Very High Very High Very High
Sumatriptan 32 99.62 Very High Very High Very High
Fibrositis 11 97.94 Very High Very High Very High
headache 44 94.88 High High
carpal tunnel syndrome 12 92.72 High High
Disease Link Frequency Relevance Heat
Cancer 422 100.00 Very High Very High Very High
Juvenile Chronic Polyarthritis 15 99.98 Very High Very High Very High
Aging 650 99.96 Very High Very High Very High
Growth Hormone Deficiency 10 99.96 Very High Very High Very High
Pain 25 99.84 Very High Very High Very High
Disease 222 99.56 Very High Very High Very High
Growth Problems 14 99.56 Very High Very High Very High
Meningomyelocele 10 99.40 Very High Very High Very High
Hydrocephalus 8 99.18 Very High Very High Very High
Acromegaly 546 99.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Age-related decline in GH levels is very well documented, consistent across different mammalian species and primarily due to reduced hypothalamic secretion of GH-releasing hormone (GHRH) with consequent decline of GH biosynthesis and release by the anterior pituitary (Sonntag et al 1980; Glustina and Veldhuis 1998; Kuwahara et al 2004; Frutos et al 2007).
Negative_regulation (decline) of Gene_expression (biosynthesis) of GH in anterior pituitary
1) Confidence 0.42 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682398 Disease Relevance 0.39 Pain Relevance 0
In conclusion, pain during GH injection can be significantly diminished by automatic needle insertion, which may improve compliance in long-term GH treatment.
Negative_regulation (diminished) of Gene_expression (injection) of GH associated with pain
2) Confidence 0.42 Published 1995 Journal Acta Paediatr. Section Abstract Doc Link 7780258 Disease Relevance 0.57 Pain Relevance 0.66
In conclusion, octreotide is effective in the treatment of acromegaly; however, it is better used in patients who have serum GH levels < 20 mU/L, or after a trans-sphenoidal adenomectomy, and may be combined with bromocriptine to treat the patient.
Negative_regulation (have) of Gene_expression (levels) of GH associated with acromegaly
3) Confidence 0.40 Published 1992 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 1358345 Disease Relevance 0.44 Pain Relevance 0.18
A deficiency of growth hormone (GH) is common before, and almost universal after, treatment of the tumour, and is usually treated with GH.
Negative_regulation (deficiency) of Gene_expression (treated) of GH associated with cancer
4) Confidence 0.40 Published 1996 Journal Acta Paediatr Suppl Section Abstract Doc Link 9055921 Disease Relevance 0.35 Pain Relevance 0
A deficiency of growth hormone (GH) is common before, and almost universal after, treatment of the tumour, and is usually treated with GH.
Negative_regulation (deficiency) of Gene_expression (treated) of growth hormone associated with cancer
5) Confidence 0.40 Published 1996 Journal Acta Paediatr Suppl Section Abstract Doc Link 9055921 Disease Relevance 0.35 Pain Relevance 0
A deficiency of growth hormone (GH) is common before, and almost universal after, treatment of the tumour, and is usually treated with GH.
Negative_regulation (deficiency) of Gene_expression (treated) of GH associated with cancer
6) Confidence 0.40 Published 1996 Journal Acta Paediatr Suppl Section Abstract Doc Link 9055921 Disease Relevance 0.35 Pain Relevance 0
Normal mean GH concentration, as defined by the authors (generally below 2.5 ?
Negative_regulation (defined) of Gene_expression (concentration) of GH
7) Confidence 0.38 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0 Pain Relevance 0
Whether the GH level normalizes post irradiation mainly depends on pre-irradiation serum GH concentration and the time interval between radiotherapy and the measurement of GH and IGF-1 levels.
Negative_regulation (measurement) of Gene_expression (levels) of GH
8) Confidence 0.38 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.15 Pain Relevance 0
This decline in GH production is initially clinically silent, but may contribute over time to sarcopenia and frailty.
Negative_regulation (decline) of Gene_expression (production) of GH associated with frailty
9) Confidence 0.37 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.98 Pain Relevance 0
The decline in GH production parallels the age-related decline in body mass index and is associated with alterations in body composition, hormonal status, and functional capacity that mimic the changes seen in AGHD or partial hypogonadism (Merriam et al 1997).
Negative_regulation (decline) of Gene_expression (production) of GH in body associated with reprotox - general 2 and obesity
10) Confidence 0.37 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.60 Pain Relevance 0
CB154 reduced both GH and PRL serum levels, naloxone only GH serum levels.
Negative_regulation (reduced) of Gene_expression (levels) of GH associated with narcan
11) Confidence 0.35 Published 1981 Journal Med. Biol. Section Abstract Doc Link 7266088 Disease Relevance 0.18 Pain Relevance 0.46
The serum IGF-I concentration reflects the 24-hour GH secretion and is increased or decreased, when GH production is elevated or decreased, respectively.
Negative_regulation (decreased) of Gene_expression (production) of GH
12) Confidence 0.32 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.52 Pain Relevance 0.06
A series of elegant studies by Sacca and colleagues (Sacca et al 1994, 2003) provided evidence that both GH deficiency and GH excess are detrimental for cardiac function in the human with GH-deficient patients benefiting from GH therapy and acromegalics benefiting from suppression of GH levels.
Negative_regulation (suppression) of Gene_expression (levels) of GH
13) Confidence 0.31 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682398 Disease Relevance 1.21 Pain Relevance 0
Can GH therapy prevent or perhaps even reverse aging?
Negative_regulation (reverse) of Gene_expression (therapy) of GH associated with aging
14) Confidence 0.31 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682398 Disease Relevance 0.51 Pain Relevance 0
Can GH therapy prevent or perhaps even reverse aging?
Negative_regulation (prevent) of Gene_expression (therapy) of GH associated with aging
15) Confidence 0.31 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682398 Disease Relevance 0.51 Pain Relevance 0
Age-related decline in GH levels is very well documented, consistent across different mammalian species and primarily due to reduced hypothalamic secretion of GH-releasing hormone (GHRH) with consequent decline of GH biosynthesis and release by the anterior pituitary (Sonntag et al 1980; Glustina and Veldhuis 1998; Kuwahara et al 2004; Frutos et al 2007).
Negative_regulation (decline) of Gene_expression (levels) of GH in anterior pituitary
16) Confidence 0.31 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682398 Disease Relevance 0.41 Pain Relevance 0
Peripheral tissues showed diverse evidence of chronic lack of GH stimulation: Liver GH receptors were hypersensitive to GH stimulation (Figure 4C), and several markers of peripheral GH action were abnormally low in adults (IGFBP-3, ?
Negative_regulation (markers) of Gene_expression (action) of GH in Liver
17) Confidence 0.28 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0 Pain Relevance 0.16
The inhibition of IGF-I production can create a syndrome of relative GH resistance, causing increased GH secretion with decreased GH effects.
Negative_regulation (decreased) of Gene_expression (effects) of GH associated with syndrome
18) Confidence 0.27 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.25 Pain Relevance 0
GH secretion rates decline exponentially from a peak of about 150 ?
Negative_regulation (decline) of Gene_expression (rates) of GH
19) Confidence 0.27 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.41 Pain Relevance 0
In comparison, in the lit/lit dwarf mice with a mutation in the GHRH gene (GeneID: 14601), the anterior pituitary is hypoplastic and GH-producing cells are reduced in number and are abnormally distributed [38].
Negative_regulation (reduced) of Gene_expression (producing) of GH in anterior pituitary
20) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.88 Pain Relevance 0.03

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