INT149903

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Context Info
Confidence 0.80
First Reported 2006
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 3
Total Number 15
Disease Relevance 1.10
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cav3) Golgi apparatus (Cav3) plasma membrane organization (Cav3)
plasma membrane (Cav3) enzyme binding (Cav3) protein complex (Cav3)
Anatomy Link Frequency
chondrocytes 7
plasma 2
temporomandibular joint 1
lining cells 1
Cav3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 8 98.72 Very High Very High Very High
Arthritis 13 93.44 High High
Pain 13 92.92 High High
COX-2 inhibitor 13 91.68 High High
Inflammation 65 89.68 High High
Osteoarthritis 52 5.00 Very Low Very Low Very Low
rheumatoid arthritis 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 8 98.72 Very High Very High Very High
Arthritis 39 93.44 High High
Pain 13 92.92 High High
INFLAMMATION 39 89.68 High High
Shock 2 62.08 Quite High
Stroke 13 9.76 Low Low
Volume Depletion And Dehydration 13 5.40 Low Low
Osteoarthritis 52 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study therefore examined the chronological alterations in the localization of Cav3 in the synovial lining cells of the rat TMJ during postnatal development by immunocytochemical techniques.
Localization (localization) of Cav3 in lining cells associated with snapping jaw
1) Confidence 0.80 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18286598 Disease Relevance 0.41 Pain Relevance 0.35
Immunocytochemical localization of caveolin-3 in the synoviocytes of the rat temporomandibular joint during development.
Localization (localization) of caveolin-3 in temporomandibular joint associated with snapping jaw
2) Confidence 0.80 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Title Doc Link 18286598 Disease Relevance 0.41 Pain Relevance 0.36
Confocal and electron Microscopy to determine the localization of COX-2 and Cav-3
Spec (determine) Localization (localization) of Cav-3
3) Confidence 0.70 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
To confirm the localization of COX-2 and Cav-3 in the rat chondrocytes treated with Cd (5 ┬ÁM for 6 hr), the cells were observed with confocal and electron microscopes by separately staining with the respective antibodies of COX-2 and Cav-3 and with using fluorescence- or gold particle-conjugated secondary antibodies.
Localization (localization) of Cav-3 in chondrocytes
4) Confidence 0.70 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Co-localization of COX-2 and Cav-3 in the caveolae-enriched membrane fractions of rat chondrocytes
Localization (localization) of Cav-3 in chondrocytes
5) Confidence 0.70 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
The purpose of this study, was to investigate the cellular localization of the inducible form of COX-2 and Cav-3 in cultured rat chondrocytes as a first step to demonstrating the relationship between COX-2 and Cav-3.


Spec (investigate) Localization (localization) of Cav-3 in chondrocytes
6) Confidence 0.70 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0.28 Pain Relevance 0.23
Immuno-precipitation of COX-2 and Caveolin-3
Localization (precipitation) of Caveolin-3
7) Confidence 0.65 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Thereafter, the samples were centrifuged and the pellets were washed 4 times with PIPA buffer (150 mM NaCl, 1 mM EDTA, 60 mM OG, 1% NP-40, 0.05% SDS, and 10 mM Tris; pH 8.0) and then prepared for the Western blotting analysis by boiling in the sample buffer to determine whether interactive binding has occurred between COX-2 and Cav-3.


Localization (occurred) of Cav-3
8) Confidence 0.65 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
The reasons for this un-expected co-localization of COX-2 in the caveolae by its binding to Cav-3 are not clear.
Localization (localization) of Cav-3
9) Confidence 0.65 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
The merged image (orange color) showed that at least some portion of COX-2 and Cav-3 were co-localized in the plasma membrane (Fig. 5A-c).
Localization (localized) of Cav-3 in plasma
10) Confidence 0.61 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Evidence for Cyclooxygenase-2 Association with Caveolin-3 in Primary Cultured Rat Chondrocytes

The purpose of this study was to demonstrate the cellular localization of cyclooxygenase-2 (COX-2) and caveolin-3 (Cav-3) in primarily cultured rat chondrocytes.

Localization (localization) of caveolin-3 in chondrocytes
11) Confidence 0.61 Published 2006 Journal Journal of Korean Medical Science Section Title Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Evidence for Cyclooxygenase-2 Association with Caveolin-3 in Primary Cultured Rat Chondrocytes

The purpose of this study was to demonstrate the cellular localization of cyclooxygenase-2 (COX-2) and caveolin-3 (Cav-3) in primarily cultured rat chondrocytes.

Localization (localization) of caveolin-3 in chondrocytes
12) Confidence 0.61 Published 2006 Journal Journal of Korean Medical Science Section Title Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Confocal and electron microscopy also demonstrated the co-localization of COX-2 and Cav-3 in the plasma membrane.
Localization (localization) of Cav-3 in plasma
13) Confidence 0.61 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Evidence for Cyclooxygenase-2 Association with Caveolin-3 in Primary Cultured Rat Chondrocytes

The purpose of this study was to demonstrate the cellular localization of cyclooxygenase-2 (COX-2) and caveolin-3 (Cav-3) in primarily cultured rat chondrocytes.

Localization (localization) of Cav-3 in chondrocytes
14) Confidence 0.61 Published 2006 Journal Journal of Korean Medical Science Section Title Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0
Evidence for Cyclooxygenase-2 Association with Caveolin-3 in Primary Cultured Rat Chondrocytes

The purpose of this study was to demonstrate the cellular localization of cyclooxygenase-2 (COX-2) and caveolin-3 (Cav-3) in primarily cultured rat chondrocytes.

Localization (localization) of Cav-3 in chondrocytes
15) Confidence 0.61 Published 2006 Journal Journal of Korean Medical Science Section Title Doc Link PMC2733955 Disease Relevance 0 Pain Relevance 0

General Comments

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