INT149924

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.81
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4d) Golgi apparatus (Pde4d) plasma membrane (Pde4d)
cytoskeleton (Pde4d) cytoplasm (Pde4d)
Pde4d (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 10 99.70 Very High Very High Very High
Pain 6 99.70 Very High Very High Very High
IPN 2 99.04 Very High Very High Very High
Analgesic 2 97.40 Very High Very High Very High
acular 2 94.64 High High
adenocard 2 92.92 High High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.04 Very High Very High Very High
Cancer 2 98.28 Very High Very High Very High
Necrosis 2 98.04 Very High Very High Very High
INFLAMMATION 4 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They both, however, downregulated the gene and protein expression of phosphodiesterase type 4 (PDE4D), which might represent a novel mechanism contributing to their analgesic and anti-inflammatory effects.
Negative_regulation (downregulated) of Gene_expression (expression) of PDE4D associated with inflammation and analgesic
1) Confidence 0.26 Published 2008 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 18288087 Disease Relevance 0.42 Pain Relevance 0.40
COX inhibitors downregulate PDE4D expression in a clinical model of inflammatory pain.
Negative_regulation (downregulate) of Gene_expression (expression) of PDE4D associated with inflammation and ipn
2) Confidence 0.23 Published 2008 Journal Clin. Pharmacol. Ther. Section Title Doc Link 18288087 Disease Relevance 0.39 Pain Relevance 0.84

General Comments

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