INT149928

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Cyp2e1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 8 99.98 Very High Very High Very High
Substantia nigra 8 98.12 Very High Very High Very High
nMDA receptor antagonist 3 69.16 Quite High
tetrodotoxin 1 68.24 Quite High
isoflurane 1 60.48 Quite High
ischemia 4 14.40 Low Low
addiction 6 5.00 Very Low Very Low Very Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 1 91.84 High High
Disease 68 89.88 High High
Disorders Of Creatine Metabolism 2 88.20 High High
Necrosis 1 25.48 Quite Low
Cv General 4 Under Development 2 15.84 Low Low
Cv Unclassified Under Development 3 14.40 Low Low
Cognitive Disorder 9 6.16 Low Low
Dementia 10 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aims of the present study were by using in vivo microdialysis in rat, to elucidate the mechanisms responsible for the increase in extracellular DA induced by CYP2E1 inhibition and to explore whether ROS is produced in the SN, both with and without the presence of an exogenous CYP2E1 substrate.
Positive_regulation (induced) of Negative_regulation (inhibition) of CYP2E1 associated with dopamine and substantia nigra
1) Confidence 0.50 Published 2008 Journal Synapse Section Abstract Doc Link 18288650 Disease Relevance 0.17 Pain Relevance 0.64
Studies have shown that memantine produces minimal inhibition of CYP450 enzymes CYP1A2, CYP2A6, CYP2C9, CYP2D6, CYP2E1, and CYP3A4, indicating that no pharmacokinetic interactions with drugs metabolized by these enzymes are expected.
Positive_regulation (produces) of Negative_regulation (inhibition) of CYP2E1
2) Confidence 0.31 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654628 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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