INT149944

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.09
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Map2) intracellular (Map2) protein complex (Map2)
cytoplasm (Map2)
Anatomy Link Frequency
neuronal 2
neurites 2
Map2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 44 99.98 Very High Very High Very High
ischemia 61 98.32 Very High Very High Very High
Kinase C 4 98.00 Very High Very High Very High
Catecholamine 6 93.20 High High
agonist 19 91.36 High High
Clonidine 4 90.52 High High
antagonist 15 87.88 High High
Hippocampus 4 77.60 Quite High
5HT 46 74.40 Quite High
Glutamate 7 74.24 Quite High
Disease Link Frequency Relevance Heat
Pheochromocytoma 4 99.68 Very High Very High Very High
Stress 4 99.08 Very High Very High Very High
Cv Unclassified Under Development 49 98.32 Very High Very High Very High
Death 13 85.76 High High
Apoptosis 1 78.20 Quite High
Depression 19 63.16 Quite High
Injury 2 58.80 Quite High
Transient Ischemic Attack 10 50.00 Quite Low
Cv General 4 Under Development 2 12.28 Low Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that epinephrine could significantly increase the phosphorylation of MAP-2c at ser136 in a dose- and time-dependent manner in differentiated PC12 cells as well as microtubule arrays.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of MAP-2c
1) Confidence 0.69 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.24
Moreover phosphorylation of ERK and PKC was induced by epinephrine, and ERK and PKC specific inhibitors concentration-dependently prevented epinephrine-induced phosphorylation of MAP-2c at ser136.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of MAP-2c
2) Confidence 0.69 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.25
Epinephrine increases phosphorylation of MAP-2c in rat pheochromocytoma cells (PC12 Cells) via a protein kinase C- and mitogen activated protein kinase-dependent mechanism.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of MAP-2c associated with kinase c and pheochromocytoma
3) Confidence 0.69 Published 2008 Journal J. Proteome Res. Section Title Doc Link 18290605 Disease Relevance 0.10 Pain Relevance 0.22
These findings suggest that epinephrine induces phosphorylation of MAP-2c at ser136 through a alpha 2-adrenoceptor mediated, ERK/PKC-dependent signaling pathway, which may contribute to the stabilization of neurites.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of MAP-2c in neurites
4) Confidence 0.69 Published 2008 Journal J. Proteome Res. Section Abstract Doc Link 18290605 Disease Relevance 0.07 Pain Relevance 0.20
On the other hand, fluoxetine was reported to have the ability to reverse stress-induced changes [56, 57] and that fluoxetine increases the phosphorylation of MAP-2 [58] that is amongst neuronal microtubule-associated proteins (MAPs) an abundant group of cytoskeletal components.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of MAP-2 in neuronal associated with stress and fluoxetine
5) Confidence 0.57 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928987 Disease Relevance 0.16 Pain Relevance 0.37
The ischemia-induced rapid elevation of intracellular Ca2+ concentration and subsequent activation of Ca2+-dependent phosphatases (e.g., calcineurin) and proteases (e.g., calpains) can lead to dephosphorylation and proteolytic degradation of MAP2 [18,19].
Positive_regulation (lead) of Phosphorylation (dephosphorylation) of MAP2 associated with ischemia
6) Confidence 0.32 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.61 Pain Relevance 0.16
Thus, we speculate that 5-HT2 receptors might activate ERK, leading to increased phosphorylation of MAP2 and its association with microtubules.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of MAP2
7) Confidence 0.14 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427346 Disease Relevance 0 Pain Relevance 0.24

General Comments

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