INT149951

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.19
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (VDR) signal transduction (VDR) cell morphogenesis (VDR)
nucleus (VDR) DNA binding (VDR)
VDR (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 65.80 Quite High
Angina 2 12.64 Low Low
depression 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 6 75.00 Quite High
Hypophosphatemia 2 71.16 Quite High
Frailty 67 70.88 Quite High
Hypercalcemia 6 70.44 Quite High
Hypocalcemia 2 69.20 Quite High
Congenital Anomalies 2 66.32 Quite High
Pain 2 65.80 Quite High
Muscle Weakness 3 65.36 Quite High
Osteoporosis 42 50.00 Quite Low
Inborn Error Of Metabolism 2 46.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The functional characterization of the patient's VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action.
Negative_regulation (information) of Transcription (essentiality) of VDR
1) Confidence 0.43 Published 2007 Journal J. Bone Miner. Res. Section Abstract Doc Link 18290711 Disease Relevance 0.56 Pain Relevance 0.07
The functional characterization of the patient's VDR reflected the localization of the mutation (18 different ones described to date), thus providing vital information about the structure-function relationship in the human VDR and the essentiality of the VDR as the mediator of vitamin D action.
Negative_regulation (information) of Transcription (essentiality) of VDR
2) Confidence 0.43 Published 2007 Journal J. Bone Miner. Res. Section Abstract Doc Link 18290711 Disease Relevance 0.56 Pain Relevance 0.07
Clinical study demonstrates a reduction in total fracture following prescription of 100,000 IU vitamin D orally every 4 months in community-dwelling subjects with a relative risk of 0.78 (95% CI, 0.61,0.99) [53].
Negative_regulation (reduction) of Transcription (prescription) of vitamin D
3) Confidence 0.02 Published 2010 Journal Osteoporos Int Section Body Doc Link PMC2974929 Disease Relevance 0.07 Pain Relevance 0

General Comments

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