INT14997

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Context Info
Confidence 0.66
First Reported 1983
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 21
Total Number 23
Disease Relevance 9.82
Pain Relevance 13.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (FPR1) signal transduction (FPR1) plasma membrane (FPR1)
signal transducer activity (FPR1)
Anatomy Link Frequency
neutrophils 7
monocytes 2
macrophages 1
granulocyte 1
fourth ventricle 1
FPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 164 100.00 Very High Very High Very High
Morphine 5 99.98 Very High Very High Very High
analgesia 200 99.40 Very High Very High Very High
Inflammation 396 99.26 Very High Very High Very High
Pain 285 98.84 Very High Very High Very High
Opioid 676 98.48 Very High Very High Very High
Enkephalin 411 98.16 Very High Very High Very High
IPN 190 96.84 Very High Very High Very High
substance P 8 96.80 Very High Very High Very High
anesthesia 11 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 7 100.00 Very High Very High Very High
Urological Neuroanatomy 7 99.96 Very High Very High Very High
Neuroblastoma 3 99.44 Very High Very High Very High
INFLAMMATION 400 99.26 Very High Very High Very High
Sickle Cell Anemia 7 98.86 Very High Very High Very High
Pain 294 98.84 Very High Very High Very High
Obstructive Sleep Apnea 73 97.76 Very High Very High Very High
Inflammatory Pain 190 96.84 Very High Very High Very High
Arthritis 30 94.00 High High
Hemorrhage 3 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with reserpine, which increases conversion of peptide B to the heptapeptide in bovine chromaffin cells in culture does not stimulate the accumulation of Met-enkephalyl-Arg6-Phe7 in the human neuroblastoma cells.
Positive_regulation (accumulation) of Met-enkephalyl-Arg6-Phe7 in chromaffin cells associated with neuroblastoma
1) Confidence 0.66 Published 1986 Journal Regul. Pept. Section Abstract Doc Link 2436254 Disease Relevance 0.25 Pain Relevance 0.07
In addition, these compounds inhibited the f-Met-Leu-Phe (FMLP)-induced MPO release from PMN.
Positive_regulation (-induced) of FMLP in PMN associated with urological neuroanatomy
2) Confidence 0.49 Published 1991 Journal J. Antibiot. Section Abstract Doc Link 1712007 Disease Relevance 0.44 Pain Relevance 0.49
Recently, much more attention has been focused on the human formyl peptide receptor (FPR) and its variant formyl peptide receptor-like 1 (FPRL1) and formyl peptide receptor-like 2 (FPRL2).
Positive_regulation (focused) of FPR
3) Confidence 0.49 Published 2008 Journal Pharmazie Section Abstract Doc Link 19069235 Disease Relevance 0 Pain Relevance 0
The N-formylmethionyl ligands are small hydrophilic peptides of bacterial origin, but recently a number of new peptide agonists have been identified that selectively activate the high-affinity fMLF receptor FPR and/or its low-affinity variant FPRL1.
Positive_regulation (activate) of FPR associated with agonist
4) Confidence 0.45 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0.25 Pain Relevance 0.18
In summary, mycobacteria activate FPR on neutrophils, resulting in tonic secretion of opioid peptides from neutrophils and in a decrease in inflammatory pain.
Positive_regulation (activate) of FPR in neutrophils associated with ipn and opioid
5) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2657213 Disease Relevance 0.87 Pain Relevance 1.94
This requires activation of FPR as well as intracellular Ca2+ mobilization and PI3K activation, while TLR-2 and -4 do not seem to be involved.
Positive_regulation (activation) of FPR
6) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 1.32 Pain Relevance 1.08
A FPR was suggested to be mediated by axons passing between the nucleus fastigii and the fourth ventricle.
Positive_regulation (mediated) of FPR in fourth ventricle
7) Confidence 0.41 Published 1993 Journal Neurosurgery Section Abstract Doc Link 8474661 Disease Relevance 0.41 Pain Relevance 0.14
In the present study in rats, we delineated a molecular pathway of tonic opioid release from neutrophils in complete Freund's adjuvant-induced inflammation involving mycobacterially triggered FPR activation.
Positive_regulation (activation) of FPR in neutrophils associated with inflammation and opioid
8) Confidence 0.31 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.95 Pain Relevance 1.40
Patients with SCD in vaso-occlusive crisis had PMN aggregation induced by FMLP with or without CB that was significantly increased compared with the cohort of pain-free SCD patients (p less than 0.001).
Positive_regulation (increased) of FMLP in PMN associated with sickle cell anemia and pain
9) Confidence 0.30 Published 1987 Journal Am. J. Med. Sci. Section Abstract Doc Link 3661621 Disease Relevance 0.96 Pain Relevance 0.35
Activation of human neutrophils with mycobacteria or fMLP induced a more than fivefold increase in Met-enkephalin secretion (Fig. 2B and 2H, respectively).
Positive_regulation (Activation) of fMLP in neutrophils associated with enkephalin
10) Confidence 0.29 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.20 Pain Relevance 0.43
In this study we examined whether heat inactivated Mycobacterium butyricum triggers opioid peptide release from rat and human neutrophils and monocytes and whether this requires FPR and/or TLR activation.
Spec (whether) Positive_regulation (requires) of FPR in monocytes associated with opioid
11) Confidence 0.29 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.21 Pain Relevance 0.64
Mycobacteria also contain formylated peptides activating FPR [23],[37].
Positive_regulation (activating) of FPR
12) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.05 Pain Relevance 0.84
Mycobacteria activate both TLR [21],[22] and FPR [23] that are expressed on neutrophils and monocytes/macrophages [24]–[26].
Positive_regulation (activate) of FPR in macrophages
13) Confidence 0.27 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.37 Pain Relevance 1.13
The specific phosphoinositide-3 kinase (PI3K) inhibitor wortmannin exhibited the same behavior of quercetin in anti-IgE and fMLP activation, thus suggesting a role for PI3K involvement in the priming mechanism.


Positive_regulation (activation) of fMLP
14) Confidence 0.24 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2949734 Disease Relevance 0 Pain Relevance 0.04
In this study we examined whether heat inactivated Mycobacterium butyricum triggers opioid peptide release from rat and human neutrophils and monocytes and whether this requires FPR and/or TLR activation.
Spec (whether) Positive_regulation (requires) of FPR in neutrophils associated with opioid
15) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.21 Pain Relevance 0.64
Mycobacteria activate both TLR [21],[22] and FPR [23] that are expressed on neutrophils and monocytes/macrophages [24]–[26].
Positive_regulation (activate) of FPR in neutrophils
16) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.37 Pain Relevance 1.13
Mycobacteria activate both TLR [21],[22] and FPR [23] that are expressed on neutrophils and monocytes/macrophages [24]–[26].
Positive_regulation (activate) of FPR in monocytes
17) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.37 Pain Relevance 1.13
RESULTS: Pretreatment with LAs significantly reduced the FMLP-induced PAP increase (treatment group v sham group: 0.5 to 5 mm Hg v 8 mm Hg; P < .05) and the release of endothelin-1 (2.4 v 5 fmol/mL).
Positive_regulation (increase) of FMLP
18) Confidence 0.09 Published 2006 Journal Reg Anesth Pain Med Section Body Doc Link 16701192 Disease Relevance 0 Pain Relevance 0
Chronic morphine potentiated the LEA response to either IL-1beta or FMLP alone, and greatly enhanced LEA in response to combined IL-1beta and FMLP.
Positive_regulation (potentiated) of FMLP associated with adhesions and morphine
19) Confidence 0.06 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11498262 Disease Relevance 0.90 Pain Relevance 0.71
Met-Enk-Arg-Gly-Leu was distributed in parallel with Met-Enk, Leu-Enk and Met-Enk-Arg-Phe in human and bovine brains.
Positive_regulation (distributed) of Met-Enk-Arg-Gly-Leu in brains
20) Confidence 0.04 Published 1983 Journal Life Sci. Section Abstract Doc Link 6664241 Disease Relevance 0 Pain Relevance 0.77

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