INT149975

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppif) protein folding (Ppif) mitochondrion (Ppif)
Ppif (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 4 99.32 Very High Very High Very High
tramadol 20 99.10 Very High Very High Very High
Potency 2 98.86 Very High Very High Very High
narcan 3 90.08 High High
Codeine 4 90.04 High High
Antinociceptive 1 88.00 High High
Morphine 1 70.64 Quite High
Analgesic 5 63.48 Quite High
depression 1 58.32 Quite High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Convulsion 6 92.24 High High
Respiratory Failure 1 58.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relative potency of tramadol to opioids was not altered by quinidine (an inhibitor of CYP4502D6), noxious stimulus (48 degrees C hot-plate), multiple dosing, or in reserpinized mice.
Negative_regulation (inhibitor) of CYP4502D6 associated with tramadol, opioid and potency
1) Confidence 0.41 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18292293 Disease Relevance 0.44 Pain Relevance 2.36

General Comments

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