INT149986

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 8.18
Pain Relevance 4.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr9) signal transduction (Tlr9) endoplasmic reticulum (Tlr9)
plasma membrane (Tlr9) intracellular (Tlr9) lysosome (Tlr9)
Anatomy Link Frequency
B cells 2
lungs 2
Tlr9 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 187 99.98 Very High Very High Very High
Inflammation 40 97.68 Very High Very High Very High
cytokine 35 96.64 Very High Very High Very High
Opioid 54 96.12 Very High Very High Very High
Inflammatory response 6 69.92 Quite High
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
opiate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 99 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 61 99.40 Very High Very High Very High
Mycobacterial Infection 132 97.80 Very High Very High Very High
INFLAMMATION 46 97.68 Very High Very High Very High
Apoptosis 116 96.88 Very High Very High Very High
Bacterial Meningitis 5 92.04 High High
Disease 16 89.72 High High
Immunodeficiency 1 88.84 High High
Targeted Disruption 60 82.00 Quite High
Disease Progression 2 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest a prominent role of morphine and H37Ra infection in the induction of TLR9 expression.


Positive_regulation (induction) of Gene_expression (expression) of TLR9 associated with infection and morphine
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 1.82 Pain Relevance 1.23
It has been shown that morphine increase the expression of TLR9 [24].
Positive_regulation (increase) of Gene_expression (expression) of TLR9 associated with morphine
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 2.47 Pain Relevance 1.12
As shown in Fig. 1 B, the expression of TLR9 in the lungs was significantly enhanced after morphine treatment and H37Ra infection as detected by quantitative real time RT-PCR.
Positive_regulation (enhanced) of Gene_expression (expression) of TLR9 in lungs associated with infection and morphine
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 1.90 Pain Relevance 1.22
Although there was no correlation with particular SNPs, other groups showed that there was an upregulation of TLR 9 expression in B cells of lupus patients lending credence to the idea that TLR 9 could be involved in autoantibody production [68–70].
Positive_regulation (upregulation) of Gene_expression (expression) of TLR 9 in B cells associated with systemic lupus erythematosus
4) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 1.23 Pain Relevance 0
S. pneumoniae infection resulted in a significant induction of NF-kappaB activity only in TLR9 stably transfected HEK 293 cells, but not in TLR2 and TLR4 transfected HEK 293 cells, and morphine treatment inhibited S. pneumoniae-induced NF-kappaB activity in these cells.
Positive_regulation (transfected) of Gene_expression (transfected) of TLR9 associated with infection and morphine
5) Confidence 0.16 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18292587 Disease Relevance 0.77 Pain Relevance 0.58

General Comments

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