INT149999

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 5.46
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAD) cytosol (BAD) mitochondrion (BAD)
cytoplasm (BAD)
Anatomy Link Frequency
macrophages 2
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 3 98.86 Very High Very High Very High
ischemia 45 96.56 Very High Very High Very High
Central nervous system 1 93.12 High High
cerebral cortex 4 75.00 Quite High
Inflammatory marker 4 50.00 Quite Low
cva 4 36.88 Quite Low
Inflammation 7 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 183 100.00 Very High Very High Very High
Death 24 100.00 Very High Very High Very High
Hypoxia 27 99.62 Very High Very High Very High
Infection 26 98.60 Very High Very High Very High
Mycobacterial Infection 2 98.40 Very High Very High Very High
Cv General 4 Under Development 1 96.56 Very High Very High Very High
Stress 9 95.68 Very High Very High Very High
Injury 3 94.68 High High
Gonorrhea 1 83.96 Quite High
Necrosis 9 79.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It up-regulates the anti-apoptotic Bcl-2 proteins, Bcl-2, and Bclxl and decreases pro-apoptotic Bax and Bad expression (Bazan 2005).
Negative_regulation (decreases) of Gene_expression (expression) of Bad associated with apoptosis
1) Confidence 0.13 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 1.07 Pain Relevance 0.09
M. tuberculosis infection of epithelial cells results in increased expression of BCL2 and pRb, decreased expression of BAX and BAD, and no change in p53 expression despite a large increase in expression of p53 in infected macrophages.
Negative_regulation (decreased) of Gene_expression (expression) of BAD in macrophages associated with mycobacterial infection and infection
2) Confidence 0.07 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 1.18 Pain Relevance 0
In Clonidine pretreated hypoxic group, the hypoxia-induced increased expression of pro-apoptotic proteins Bad and Bax was prevented in all the three fractions.
Negative_regulation (prevented) of Gene_expression (expression) of Bad associated with hypoxia, apoptosis and clonidine
3) Confidence 0.04 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18293086 Disease Relevance 1.88 Pain Relevance 0.33
However, actions of cycloheximide relevant to apoptosis other than the inhibition of death protein synthesis have also been recognized.
Negative_regulation (inhibition) of Gene_expression (synthesis) of death protein associated with apoptosis and death
4) Confidence 0.03 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729957 Disease Relevance 1.34 Pain Relevance 0.03

General Comments

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