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Context Info
Confidence 0.57
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.34
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL11) extracellular space (CXCL11) extracellular region (CXCL11)
cell-cell signaling (CXCL11)
Anatomy Link Frequency
heart 1
CXCL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 3 99.62 Very High Very High Very High
tolerance 3 98.20 Very High Very High Very High
Angina 10 97.12 Very High Very High Very High
guanethidine 1 90.36 High High
Calcium channel 2 88.96 High High
chemokine 99 84.24 Quite High
depression 1 59.72 Quite High
Inflammation 10 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypotension 3 98.52 Very High Very High Very High
Arrhythmias 2 Under Development 2 97.38 Very High Very High Very High
Cancer 157 97.24 Very High Very High Very High
Cv General 3 Under Development 9 97.12 Very High Very High Very High
Ovarian Cancer 85 96.56 Very High Very High Very High
Hypertension 7 87.32 High High
Metastasis 18 83.44 Quite High
Coronary Heart Disease 2 80.48 Quite High
Pheochromocytoma 2 78.96 Quite High
Acute Coronary Syndrome 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to these phenomena, we supposed that the alpha-adrenergic receptor was involved in the development of the ST-T changes of the ECG, and the alpha-adrenergic receptor of this patient might be sensitive under excessive catecholamines, according to the inhibition of the beta-receptor by propranolol.
Negative_regulation (inhibition) of beta-receptor associated with catecholamine and arrhythmias 2 under development
1) Confidence 0.57 Published 1990 Journal Nippon Naibunpi Gakkai Zasshi Section Abstract Doc Link 1968401 Disease Relevance 0.80 Pain Relevance 0.15
Both of these beta-receptor blocking drug produced an an improvement in exercise tolerance in patients with angina either alone or in combination with other hypotensive therapy.
Negative_regulation (blocking) of beta-receptor associated with angina, hypotension and tolerance
2) Confidence 0.41 Published 1976 Journal Cardiology Section Abstract Doc Link 13931 Disease Relevance 1.28 Pain Relevance 0.70
This review discusses the circadian phase dependency in the anti-anginal effects and in the pharmacokinetics of drugs used in the treatment of coronary heart diseased patients. beta-receptor blocking agents seem mainly to reduce ischaemic events during daytime hours and are of therapeutic value in the morning hours which are the hours of high cardiovascular risk.
Negative_regulation (reduce) of beta-receptor in heart
3) Confidence 0.41 Published 1998 Journal Eur. Heart J. Section Abstract Doc Link 9597426 Disease Relevance 0.07 Pain Relevance 0.08
Interestingly, the inhibition of CXCL11 activity by neutralizing antibodies significantly increases cis-platinum response in ovarian carcinoma cells [80].


Negative_regulation (inhibition) of CXCL11 associated with ovarian cancer
4) Confidence 0.20 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.19 Pain Relevance 0.18

General Comments

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