INT1500

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1978
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 4.44
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
plasma 6
blood 2
renal artery 2
sympathetic nervous system 2
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 6 99.84 Very High Very High Very High
Enkephalin 3 94.08 High High
anesthesia 6 92.40 High High
Opioid 3 79.72 Quite High
cytokine 4 77.68 Quite High
Inflammation 4 77.28 Quite High
Spinal cord 2 76.68 Quite High
cva 10 75.00 Quite High
MU agonist 2 75.00 Quite High
depression 1 53.92 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 18 99.92 Very High Very High Very High
Sepsis 77 99.16 Very High Very High Very High
Bordatella Infection 4 98.80 Very High Very High Very High
Natriuresis 7 97.56 Very High Very High Very High
Anaemia 1 96.24 Very High Very High Very High
Hypertension 40 95.20 Very High Very High Very High
Coagulation Disorder 3 94.52 High High
Increased Venous Pressure Under Development 2 93.52 High High
Infection 14 90.44 High High
Stroke 2 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Renin-depletion, described as a decrease in renal cortex and plasma renin levels, was produced by clipping one renal artery of a rat and leaving the contralateral kidney in place (two kidney one clip hypertension), One month later the clipped kidney was removed and after 24 h recovery such rats were found to be renin depleted: renal cortex and plasma renin levels were 8 and 63% of normal respectively. 2.
Negative_regulation (decrease) of in renal artery Gene_expression (levels) of Renin in plasma associated with hypertension
1) Confidence 0.43 Published 1981 Journal Pflugers Arch. Section Abstract Doc Link 7033921 Disease Relevance 0.37 Pain Relevance 0.12
Renin-depletion, described as a decrease in renal cortex and plasma renin levels, was produced by clipping one renal artery of a rat and leaving the contralateral kidney in place (two kidney one clip hypertension), One month later the clipped kidney was removed and after 24 h recovery such rats were found to be renin depleted: renal cortex and plasma renin levels were 8 and 63% of normal respectively. 2.
Negative_regulation (decrease) of in renal artery Gene_expression (levels) of renin in plasma associated with hypertension
2) Confidence 0.43 Published 1981 Journal Pflugers Arch. Section Abstract Doc Link 7033921 Disease Relevance 0.37 Pain Relevance 0.12
Propranolol partially blocked the increase in plasma renin concentration produced by anesthetics.
Negative_regulation (blocked) of Gene_expression (produced) of plasma renin in plasma
3) Confidence 0.37 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3894036 Disease Relevance 0.27 Pain Relevance 0.17
The data indicate that at least at this dose, the depressor response and the decrease in renin secretion produced by CLON are completely central in origin.
Negative_regulation (decrease) of Gene_expression (produced) of renin associated with clonidine
4) Confidence 0.29 Published 1978 Journal Neuroendocrinology Section Abstract Doc Link 206850 Disease Relevance 0.16 Pain Relevance 0.47
Blockade of the RAS in such high-renin conditions prevents the angiotensin II-dependent BP maintenance (Brunner et al 1988) and thus enhances the effect of the diuretic (Neutel et al 1999b).
Negative_regulation (Blockade) of Gene_expression (conditions) of renin
5) Confidence 0.25 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0.18 Pain Relevance 0
In rats dosed with DOCA-salt (which suppresses renin and angiotensin II production): (1) there was no synergism between the hypotensive actions of enalaprilat and doxazosin; (2) doxazosin was more potent than in untreated rats; and (3) enalaprilat lowered blood pressure, suggesting a hypotensive mechanism separate from ACE inhibition.
Negative_regulation (suppresses) of Gene_expression (production) of renin in blood
6) Confidence 0.21 Published 1992 Journal J. Hypertens. Section Body Doc Link 1315824 Disease Relevance 0.08 Pain Relevance 0
Niravoline tended to decrease plasma vasopressin levels and urinary excretion and significantly increased plasma levels of norepinephrine (+44% at 0.5 hr), active renin (+22% at 1.25 hr), aldosterone (+52% at 1.25 hr) and atrial natriuretic factor (+20% at 2 hr).
Negative_regulation (decrease) of Gene_expression (levels) of renin in plasma associated with natriuresis
7) Confidence 0.14 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764356 Disease Relevance 0.41 Pain Relevance 0.13
Oral contraceptive-induced high blood pressure is prevented by renin-angiotensin suppression in female rats but not by sympathetic nervous system blockade.
Negative_regulation (prevented) of Gene_expression (suppression) of renin-angiotensin in sympathetic nervous system associated with pressure and volume under development
8) Confidence 0.11 Published 2008 Journal Indian J. Exp. Biol. Section Title Doc Link 19090344 Disease Relevance 0.49 Pain Relevance 0.08
D-amphetamine decreased aldosterone and renin levels in both groups.
Negative_regulation (decreased) of Gene_expression (levels) of renin
9) Confidence 0.11 Published 1994 Journal Am. J. Med. Sci. Section Abstract Doc Link 8042656 Disease Relevance 0.47 Pain Relevance 0.47
Tamion and colleagues [11] measured serial renin and erythropoietin levels over 48 hours in 50 septic shock patients.
Negative_regulation (measured) of Gene_expression (levels) of renin associated with sepsis
10) Confidence 0.07 Published 2005 Journal Crit Care Section Body Doc Link PMC1269453 Disease Relevance 1.64 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox