INT15000

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Context Info
Confidence 0.72
First Reported 1986
Last Reported 2010
Negated 1
Speculated 8
Reported most in Abstract
Documents 32
Total Number 42
Disease Relevance 5.70
Pain Relevance 29.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
RVM 4
brain 3
pituitary 2
ventral 2
hippocampal formation 1
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 473 100.00 Very High Very High Very High
Opioid 425 100.00 Very High Very High Very High
Endogenous opioid 123 100.00 Very High Very High Very High
Enkephalin 74 100.00 Very High Very High Very High
Kappa opioid receptor 34 100.00 Very High Very High Very High
mu opioid receptor 22 100.00 Very High Very High Very High
projection neuron 10 99.98 Very High Very High Very High
Dopamine 7 99.84 Very High Very High Very High
Inflammation 204 99.80 Very High Very High Very High
Rostral ventromedial medulla 38 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 219 99.80 Very High Very High Very High
Urological Neuroanatomy 30 99.24 Very High Very High Very High
Nociception 28 99.00 Very High Very High Very High
Targeted Disruption 15 99.00 Very High Very High Very High
Gallstones 3 98.86 Very High Very High Very High
Stress 63 97.20 Very High Very High Very High
Mental Disorders 1 92.72 High High
Neuropathic Pain 15 92.40 High High
Bordatella Infection 5 92.08 High High
Pain 114 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further examined whether this down-regulation of receptor was due to a decrease in the transcription of gene encoding delta-opioid receptor (DOR-1).
Transcription (transcription) of DOR-1 associated with opioid receptor
1) Confidence 0.72 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.54
Increased abundance of opioid receptor heteromers after chronic morphine administration.
Transcription (abundance) of opioid receptor associated with opioid receptor and morphine
2) Confidence 0.68 Published 2010 Journal Sci Signal Section Title Doc Link 20647592 Disease Relevance 0.08 Pain Relevance 0.50
At P8, delta-opioid receptor mRNA was detected in large-sized cells of the striatum, possibly cholinergic, suggesting a possible modulation by opioids of the striatal cholinergic neurons.
Transcription (detected) of delta-opioid receptor mRNA in cholinergic neurons associated with opioid receptor and opioid
3) Confidence 0.68 Published 1998 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9729374 Disease Relevance 0 Pain Relevance 0.83
By G13, mu and kappa-opioid receptor mRNA were detectable in the telencephalon; mu-opioid receptor mRNA was found in the striatal neuroepithelium and cortical plate and kappa-opioid receptor mRNA in the corroidal fissure.
Transcription (found) of mu-opioid receptor mRNA in telencephalon associated with kappa opioid receptor and opioid receptor
4) Confidence 0.66 Published 1998 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9729374 Disease Relevance 0 Pain Relevance 0.61
Delta-opioid receptor mRNA was first detected at G21, in many areas including the accumbens nucleus and the dorsal striatum.
Transcription (detected) of Delta-opioid receptor mRNA in striatum associated with nucleus accumbens and opioid receptor
5) Confidence 0.66 Published 1998 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9729374 Disease Relevance 0 Pain Relevance 0.83
Thus, the result of this study did not suggest that alteration in transcription of gene-encoding delta-opioid receptor was responsible for the down-regulation of delta-opioid receptor associated with the development of tolerance to DADLE.
Transcription (transcription) of delta-opioid receptor associated with tolerance and opioid receptor
6) Confidence 0.63 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.65
We further examined whether this down-regulation of receptor was due to a decrease in the transcription of gene encoding delta-opioid receptor (DOR-1).
Transcription (transcription) of delta-opioid receptor associated with opioid receptor
7) Confidence 0.63 Published 1998 Journal Chin J Physiol Section Abstract Doc Link 10099869 Disease Relevance 0 Pain Relevance 0.54
In the stomach, delta and kappa but not mu opioid receptor transcripts were detected.
Transcription (detected) of opioid receptor in stomach associated with mu opioid receptor
8) Confidence 0.59 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8579608 Disease Relevance 0 Pain Relevance 0.51
The major findings of the study are: (1) striatal patches were first delineated by prodynorphin mRNA followed by mu opioid receptor mRNA expression at embryonic days 19 and 21, respectively; (2) in neonates, prodynorphin, mu and kappa opioid receptor mRNAs were transiently co-distributed within patches; (3) prodynorphin mRNA was co-expressed with mu but not kappa, receptor mRNA in neonatal patch neurons; (4) in the SN, kappa receptor and prodynorphin mRNAs were detected as early as embryonic days 15 and 19, respectively; (5) kappa receptor, but not prodynorphin, mRNA was expressed in dopaminergic neurons in the SN.
Transcription (expression) of opioid receptor in neurons associated with substantia nigra, kappa opioid receptor and mu opioid receptor
9) Confidence 0.54 Published 2003 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12954528 Disease Relevance 0 Pain Relevance 0.57
Opioid receptor expression was not detected in endothelium or synovium.
Neg (not) Transcription (detected) of Opioid receptor in synovium associated with opioid receptor
10) Confidence 0.52 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8579608 Disease Relevance 0 Pain Relevance 0.51
A semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was employed to detect changes in the expression of delta- (DOR) kappa- (KOR) and mu- (MOR) opioid receptor mRNAs in rat cochleae at P0, P4, P8 and P16.
Transcription (expression) of DOR associated with opioid receptor
11) Confidence 0.52 Published 2003 Journal Hear. Res. Section Abstract Doc Link 14553898 Disease Relevance 0 Pain Relevance 0.25
Importantly, during this treatment the mRNA expression of all three opioid receptors (MOR1, KOR1 and DOR1) was increased as assessed by real-time RTPCR though subsequent western blot analysis revealed a selective increase in the protein level of DOR1, only.
Transcription (expression) of DOR1 associated with opioid receptor
12) Confidence 0.47 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19560378 Disease Relevance 0 Pain Relevance 1.11
We have examined the distribution of mRNA encoding a mu opioid receptor in rat brain with in situ hybridization histochemistry at the single-cell level to obtain information about the cell types synthesizing this receptor.
Spec (examined) Transcription (distribution) of opioid receptor in brain associated with mu opioid receptor
13) Confidence 0.42 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 8089277 Disease Relevance 0.07 Pain Relevance 0.39
Furthermore, the inability of chronic Li treatment to modify either the content or basal release of beta-endorphin in various brain regions suggests that this antagonism is mediated directly at the level of the opioid receptor and/or its transducer systems.
Transcription (level) of opioid receptor in brain associated with opioid receptor
14) Confidence 0.41 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1848627 Disease Relevance 0 Pain Relevance 0.74
Opioid receptor and peptide mRNA expression in proliferative zones of fetal rat central nervous system.
Transcription (expression) of Opioid receptor in central nervous system associated with central nervous system and opioid receptor
15) Confidence 0.40 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 9673792 Disease Relevance 0.15 Pain Relevance 0.69
In addition, using quantitative competitive RT-PCR, we examined the levels of mu-opioid receptor (MOR) and delta-opioid receptor (DOR) mRNA in the nucleus accumbens shell (NAcSh) and ventral tegmental area (VTA) of behaviorally sensitized rats, at these two withdrawal times.
Spec (examined) Transcription (levels) of delta-opioid receptor in ventral associated with ventral tegmentum, nucleus accumbens, opioid receptor and withdrawal
16) Confidence 0.34 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12629526 Disease Relevance 0 Pain Relevance 1.12
In the present study, we examined the expression of DOR1 and MOR1 mRNAs in PAG neurons projecting to RVM using quantitative in situ hybridization and retrograde tract-tracing.
Spec (examined) Transcription (expression) of DOR1 in RVM associated with opioid receptor, central grey and rostral ventromedial medulla
17) Confidence 0.33 Published 2002 Journal Neuroscience Section Abstract Doc Link 11823071 Disease Relevance 0.72 Pain Relevance 1.43
Effect of chronic cocaine treatment on mu- and delta-opioid receptor mRNA levels in dopaminergically innervated brain regions.
Transcription (levels) of delta-opioid receptor in brain associated with opioid receptor and cocaine
18) Confidence 0.30 Published 1996 Journal J. Neurochem. Section Title Doc Link 8592112 Disease Relevance 0 Pain Relevance 0.80
In addition, using quantitative competitive RT-PCR, we examined the levels of mu-opioid receptor (MOR) and delta-opioid receptor (DOR) mRNA in the nucleus accumbens shell (NAcSh) and ventral tegmental area (VTA) of behaviorally sensitized rats, at these two withdrawal times.
Spec (examined) Transcription (levels) of opioid receptor in ventral associated with ventral tegmentum, nucleus accumbens, opioid receptor and withdrawal
19) Confidence 0.29 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12629526 Disease Relevance 0 Pain Relevance 1.08
Neuronal types expressing mu- and delta-opioid receptor mRNA in the rat hippocampal formation.
Transcription (expressing) of delta-opioid receptor in hippocampal formation associated with opioid receptor
20) Confidence 0.24 Published 2004 Journal J. Comp. Neurol. Section Title Doc Link 14689476 Disease Relevance 0.13 Pain Relevance 0.52

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