INT150000

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 3.10
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAD) cytosol (BAD) mitochondrion (BAD)
cytoplasm (BAD)
BAD (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 52 99.00 Very High Very High Very High
agonist 2 88.00 High High
cytokine 11 85.40 High High
Clonidine 3 82.84 Quite High
Bile 1 79.12 Quite High
cerebral cortex 2 75.00 Quite High
Inflammation 26 5.00 Very Low Very Low Very Low
cINOD 17 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 162 100.00 Very High Very High Very High
Hypoxia 15 99.90 Very High Very High Very High
Stomach Cancer 5 93.56 High High
Cancer 126 81.44 Quite High
Carcinoma 4 79.72 Quite High
Death 27 72.64 Quite High
Targeted Disruption 2 67.96 Quite High
Hepatocellular Cancer 3 60.40 Quite High
Colon Cancer 23 40.64 Quite Low
Metastasis 5 8.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The COX-2 inhibitor, indeed, was able to increase the level of PTEN, leading to a decrease of Akt phosphorylation and activation of Bad [114].
Positive_regulation (leading) of Positive_regulation (activation) of Bad associated with cox-2 inhibitor
1) Confidence 0.14 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.36 Pain Relevance 0.27
We propose that during hypoxia the increased ratio of (pro-apoptotic Bad and Bax/anti-apoptotic Bcl-xl and Bcl-2) in all the three compartments, will lead to altered mitochondrial and nuclear membrane permeability as well as caspase-9 activation in the cytosolic compartment.
Positive_regulation (lead) of Positive_regulation (increased) of Bad associated with hypoxia and apoptosis
2) Confidence 0.04 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18293086 Disease Relevance 1.73 Pain Relevance 0.28

General Comments

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