INT15001

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 29
Total Number 31
Disease Relevance 6.71
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 6
dendrite 1
retina 1
stellate cells 1
neuroglial cells 1
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 7 99.80 Very High Very High Very High
Hippocampus 62 99.44 Very High Very High Very High
Spinal cord 314 99.32 Very High Very High Very High
Opioid 24 99.16 Very High Very High Very High
glial activation 5 98.56 Very High Very High Very High
spinal dorsal horn 1 97.96 Very High Very High Very High
Central nervous system 157 96.48 Very High Very High Very High
intrathecal 29 96.00 Very High Very High Very High
Sciatic nerve 34 95.36 Very High Very High Very High
Lasting pain 11 93.32 High High
Disease Link Frequency Relevance Heat
Injury 142 99.72 Very High Very High Very High
Sprains And Strains 222 98.72 Very High Very High Very High
Glaucoma 113 95.12 Very High Very High Very High
Spinal Cord Injury 60 93.76 High High
Pain 26 93.32 High High
Hyperalgesia 1 91.96 High High
Targeted Disruption 115 89.92 High High
Influenza Virus Infection 28 89.48 High High
Cv General 4 Under Development 12 89.32 High High
Neuropathic Pain 32 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The differences in abundance of Gfap and Mtap2 observed between the strains are likely to be restricted to specific mRNA forms, represented on the array by the 1440142_s_at and 1440699_at probe-sets (Figure 4).
Localization (abundance) of Gfap associated with sprains and strains
1) Confidence 0.75 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.49 Pain Relevance 0.20
Furthermore, 5-bromo-2'-deoxyuridine (BrdU)-positive cells on the ipsilateral dorsal horn of the spinal cord were significantly increased at 7 days after nerve ligation and were highly co-localized with another microglia marker, ionized calcium-binding adaptor molecule 1 (Iba1), but neither with GFAP nor a specific neural nuclei marker, NeuN, in the spinal dorsal horn of nerve-ligated mice.
Localization (co-localized) of GFAP in nerve associated with spinal dorsal horn, dorsal horn and spinal cord
2) Confidence 0.75 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16606373 Disease Relevance 0.32 Pain Relevance 0.87
Interestingly, we noticed that both the increased NOS-2 and GFAP staining were mostly found around capillary blood vessels of the hippocampus starting at an early stage.
Localization (staining) of GFAP in capillary associated with hippocampus
3) Confidence 0.73 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2295255 Disease Relevance 0.61 Pain Relevance 0.30
In contrast, in RSMHV2EGFP-infected mice EGFP completely colocalized with GFAP (Figure 19).
Localization (colocalized) of GFAP
4) Confidence 0.73 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2905936 Disease Relevance 0.60 Pain Relevance 0.10
To further investigate the cellular mechanisms underlying FGF-2 restorative actions and to analyze the changes within astroglial cells, we studied the localization of GFAP and FGF-2 in adult intact and injured Pleurodeles CNS.
Localization (localization) of GFAP
5) Confidence 0.72 Published 2010 Journal Frontiers in Cellular Neuroscience Section Abstract Doc Link PMC2990542 Disease Relevance 0.45 Pain Relevance 0.16
In order to better understand the activation process occurring in astrocytes, we measured the colocalization between FGF-2 and GFAP after lesion by assessing FGF-2 intensity in both types of cells in each region of the CNS.
Localization (colocalization) of GFAP in astrocytes associated with central nervous system
6) Confidence 0.72 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0 Pain Relevance 0.14
Colocalization of FGF-2 and GFAP was obvious in all these cells.
Localization (Colocalization) of GFAP
7) Confidence 0.72 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.23 Pain Relevance 0.19
GFAP is expressed in the normal retina mainly in astrocytes, and is localized to the vicinity of the inner limiting membrane and nerve fiber layer.
Localization (localized) of GFAP in retina
8) Confidence 0.69 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.18 Pain Relevance 0.19
To determine whether cultured astrocytes express opioid gene mRNA, a method was developed for co-localizing a cell-type specific immunocytochemical marker for astrocytes, glial fibrillary acidic protein (GFAP), and proenkephalin mRNA in situ hybridization signal using high affinity cRNA probes.
Localization (localizing) of GFAP in astrocytes associated with opioid
9) Confidence 0.68 Published 1991 Journal J. Neurosci. Methods Section Abstract Doc Link 1712058 Disease Relevance 0 Pain Relevance 0.10
Primers for the detection of GFAP were: forward 5'-AAACGAGTCCCTGGAGAG-3', reverse 5'-TCCTGGTACTCCTGCAAGT-3' (marmoset GFAP, Ensembl transcript number ENSCJAT00000024380).
Localization (detection) of GFAP
10) Confidence 0.68 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
The striking observation of the association of the increase of GFAP localization with the increase of FGF-2 immunoreactivity in all regions reveals that FGF-2 was primarily expressed in astrocytes, as previously demonstrated by Van der Wal et al. (1994).
Localization (localization) of GFAP in astrocytes
11) Confidence 0.67 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.11
Indirect immunohistochemical methods were used to define the cellular localization of GFAP (Vazquez-Chona and Geisert, 1999).
Localization (localization) of GFAP
12) Confidence 0.67 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0 Pain Relevance 0
Cellular localization of PEDF and glial fibrillary acidic protein (GFAP) was determined by immunohistochemistry.
Spec (determined) Localization (localization) of glial fibrillary acidic protein
13) Confidence 0.65 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2647972 Disease Relevance 0.80 Pain Relevance 0.08
Cellular localization of PEDF and glial fibrillary acidic protein (GFAP) was determined by immunohistochemistry.
Spec (determined) Localization (localization) of GFAP
14) Confidence 0.65 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2647972 Disease Relevance 0.80 Pain Relevance 0.08
The colocalization of FGF-2 and GFAP in the same cells (shown in orange, Figures 1A, B) suggests that the neuroglial cells lining the fourth ventricle are a major source of FGF-2 starting 1 week after spinal cord lesion.
Localization (colocalization) of GFAP in neuroglial cells associated with spinal cord
15) Confidence 0.63 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.08 Pain Relevance 0.12
m, and then reanalyzed GAD65 and GFAP colocalization (since BG fibers were arranged vertically with an average gap of approximately 5 ?
Localization (colocalization) of GFAP
16) Confidence 0.58 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.10
At P8, when stellate cells were just migrating across the PCL, CHL1 was already prominent along BG fibers (Figure 4A1; colocalization with GFAP not shown).
Localization (colocalization) of GFAP in stellate cells
17) Confidence 0.58 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.03
Such colocalization with GFAP was detected throughout postnatal development (unpublished data).
Localization (colocalization) of GFAP
18) Confidence 0.58 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.04
Labeling with GFAP antibodies revealed that most eGFP-positive cells were also labeled for GFAP (Fig. 2 B), identifying these cells as astrocytes.
Localization (labeled) of GFAP in astrocytes
19) Confidence 0.56 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0.14 Pain Relevance 0
Paired comparisons of GAD65 density and colocalization with GFAP used the Wilcoxon signed rank test.
Localization (colocalization) of GFAP
20) Confidence 0.55 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.06 Pain Relevance 0

General Comments

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