INT150022

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 69
Total Number 73
Disease Relevance 70.04
Pain Relevance 21.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17a) extracellular region (Il17a)
Anatomy Link Frequency
T cells 6
Th17 cells 4
plasma 3
synovium 3
macrophages 2
Il17a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1951 100.00 Very High Very High Very High
chemokine 294 100.00 Very High Very High Very High
psoriasis 237 99.92 Very High Very High Very High
fibrosis 139 99.92 Very High Very High Very High
rheumatoid arthritis 1327 99.86 Very High Very High Very High
Crohn's disease 255 99.80 Very High Very High Very High
Inflammation 1290 99.74 Very High Very High Very High
Inflammatory mediators 59 99.16 Very High Very High Very High
Arthritis 993 98.60 Very High Very High Very High
Angina 21 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Burns 378 99.96 Very High Very High Very High
Disease 1744 99.92 Very High Very High Very High
Psoriasis 270 99.92 Very High Very High Very High
Fibrosis 72 99.92 Very High Very High Very High
Urological Neuroanatomy 58 99.90 Very High Very High Very High
Rheumatoid Arthritis 1335 99.86 Very High Very High Very High
Acute Coronary Syndrome 24 99.84 Very High Very High Very High
Inflammatory Bowel Disease 285 99.80 Very High Very High Very High
Arthritis 860 99.74 Very High Very High Very High
INFLAMMATION 1372 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The beneficial effect of IL-23 could be accounted for by a combined induction of IL-17A and IFN?
Positive_regulation (induction) of IL-17A
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.98 Pain Relevance 0.08
Intranasal infection with LVS, which induces IL-17A expression in pulmonary lymphocytes (Figure 3), entailed accumulation of IL-17A in the BALF (Figure 4A left) that reached its peak in days 3–4.
Positive_regulation (accumulation) of IL-17A in lymphocytes associated with sprains and strains and infection
2) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.64 Pain Relevance 0.07
IL-17A induction in T cells is characterized by a sharp peak on day 4 which subsided subsequently.
Positive_regulation (induction) of IL-17A in T cells
3) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.34 Pain Relevance 0.17
Most notably, an early and robust induction of IL-17A was observed in pulmonary T cells, but not in pulmonary NK cells (Figure 3).
Positive_regulation (induction) of IL-17A in NK cells
4) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.33 Pain Relevance 0.20
Although H.pylori-associated gastritis coincides with a marked mucosal induction of IL17 and IL23 [140], and these cytokines are also elevated in gastric cancer bearing gp130Y757F mice (Putoczki T, Ernst M: A role for IL17 in a mouse model of gastric cancer, submitted), the latter tumours also develop in gp130Y757F;Rag-/- mice in the absence of adaptive immune cells [141].
Positive_regulation (induction) of IL17 in immune cells associated with cancer, gastritis, stomach cancer and cytokine
5) Confidence 0.60 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.87 Pain Relevance 0.15
Studies by Finnerty et al. have recently shown that circulating IL-17 levels are increased early after burn in pediatric patients, as well in a mouse burn model [19,20].
Positive_regulation (increased) of IL-17 associated with burns
6) Confidence 0.57 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.64 Pain Relevance 0.47
Moreover, induction of IL17A and IL21 was significantly more pronounced in UC than in colonic CD, and this induction was associated with more intense inflammation as defined by increased induction of IL8.
Positive_regulation (induction) of IL17A associated with inflammatory bowel disease, inflammation and crohn's disease
7) Confidence 0.49 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.29 Pain Relevance 0.55
Intranasal instillation of IL-17A resulted in enhanced concentrations of TNF?
Positive_regulation (instillation) of IL-17A
8) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.09 Pain Relevance 0
Since we demonstrate that the presence of IL-17A is important for protection from LVS (Figure 10), but the IL-17A-secreting ??
Positive_regulation (presence) of IL-17A associated with sprains and strains
9) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 1.00 Pain Relevance 0.14
LVS infection resulted in a distinct increase in IL-17A+ producing cells both in CD4+ T and ??
Positive_regulation (increase) of IL-17A associated with sprains and strains and infection
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.60 Pain Relevance 0.12
Conversely, we observed a lower median proportion of IL-17-producing CD4 T cells in cells isolated from RA synovium (SVMC) (0.80% (0.48 to 1.04)) compared with PBMC (1.07% (0.43 to 1.64)) from those individuals (Figure 1C).
Positive_regulation (proportion) of IL-17-producing in synovium associated with rheumatoid arthritis
11) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.55 Pain Relevance 0.27
t, which facilitates IL6-mediated polarization of naïve CD4 cells, and transcriptionally induces the IL-17a gene [134].
Positive_regulation (induces) of IL-17a
12) Confidence 0.43 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.56 Pain Relevance 0
Somewhat surprisingly elevated levels of cardiac IL-17 were observed in sham animals at 3 and 6 hrs.
Positive_regulation (elevated) of IL-17
13) Confidence 0.41 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.06 Pain Relevance 0.24
As shown in figure 2, burn induced an early myocardial inflammation as evidenced by significantly higher (P < 0.05) levels of IL-17, IL-6 and IL-22 in the burn group as compared to the sham animals.
Positive_regulation (levels) of IL-17 associated with myocarditis, inflammation and burns
14) Confidence 0.41 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.40 Pain Relevance 0.14
The results showed that the proportion of Th17 cells and the level of IL-17 were increased at 2 weeks PI compared with the controls and recovered at 8 weeks PI.
Positive_regulation (increased) of IL-17 in Th17 cells
15) Confidence 0.40 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2786920 Disease Relevance 0.15 Pain Relevance 0.08
One day after burn, IL-17 remained elevated, however, without significant difference from the respective sham group.
Positive_regulation (elevated) of IL-17 associated with burns
16) Confidence 0.38 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 0.98 Pain Relevance 0.10
As shown in figure 1, burn caused a significant (P < 0.05) elevation in the cardiac levels of IL-17, 3 hours after injury as compared to the sham animals.
Positive_regulation (elevation) of IL-17 associated with burns and injury
17) Confidence 0.38 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 0.94 Pain Relevance 0.09
IL-17 levels were also increased in the serum of SSc patients, but not in that of SLE patients or healthy donors.
Neg (not) Positive_regulation (increased) of IL-17 associated with systemic lupus erythematosus and systemic sclerosis
18) Confidence 0.36 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.84 Pain Relevance 0.34
In joint inflammation of RA, high levels of IL-17 can be found, and hardly any IFN-gamma expression can be detected in the joint synovium [10, 76].
Positive_regulation (levels) of IL-17 in joint associated with inflammation, rheumatoid arthritis and arthritis
19) Confidence 0.36 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 0.61 Pain Relevance 0.34
In contrast, elevated levels of IL-17A have been found in inflamed synovium [53].
Positive_regulation (levels) of IL-17A in synovium
20) Confidence 0.36 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.46 Pain Relevance 0.76

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