INT150023

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 18.33
Pain Relevance 6.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il23a) extracellular region (Il23a)
Anatomy Link Frequency
dendritic cells 3
joints 2
immune cell 2
Th17 cells 2
macrophages 1
Il23a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 824 100.00 Very High Very High Very High
Arthritis 172 99.98 Very High Very High Very High
Crohn's disease 111 99.32 Very High Very High Very High
Inflammatory mediators 19 99.16 Very High Very High Very High
rheumatoid arthritis 488 97.60 Very High Very High Very High
antagonist 47 97.28 Very High Very High Very High
Angina 6 96.60 Very High Very High Very High
Inflammation 499 92.84 High High
psoriasis 55 91.32 High High
cINOD 7 83.92 Quite High
Disease Link Frequency Relevance Heat
Arthritis 145 99.98 Very High Very High Very High
Candida Infection 172 99.68 Very High Very High Very High
Gastritis 2 99.34 Very High Very High Very High
Disease 445 99.32 Very High Very High Very High
Fungal Infection 12 99.20 Very High Very High Very High
Multiple Sclerosis 120 99.00 Very High Very High Very High
Keratitis 39 99.00 Very High Very High Very High
INFLAMMATION 526 98.76 Very High Very High Very High
Stomach Cancer 6 98.04 Very High Very High Very High
Inflammatory Bowel Disease 148 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, IL23A and STAT3 were not induced.
Neg (not) Positive_regulation (induced) of IL23A
1) Confidence 0.38 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 2.25 Pain Relevance 0.61
In only one study, IL17A and IL23 were mildly increased in active ileal CD samples [34].
Positive_regulation (increased) of IL23 associated with crohn's disease
2) Confidence 0.31 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.65 Pain Relevance 0.36
However, the relative contributions of IL-12 and IL-23 to the pathogenic process remain to be elucidated.
Positive_regulation (contributions) of IL-23
3) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442630 Disease Relevance 0.40 Pain Relevance 0.18
Due to the presence of T cells and sporadic numbers of dendritic cells and macrophages within infiltrates, an increase in the levels of proinflammatory cytokines such as interleukin-17 (IL-17), IL-22, and IL-23 was also detected locally and systemically.
Positive_regulation (increase) of IL-23 in macrophages associated with cytokine
4) Confidence 0.16 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.24 Pain Relevance 0.05
Interestingly, although mono-arthritis induction in IL-23-deficient mice did not result in a lower proportion of IFN-g-positive CD4+ T cells in the spleen and lymph node, a lower proportion of these cell was detected in the target organ, the joint [15].
Positive_regulation (induction) of IL-23-deficient in joint associated with arthritis
5) Confidence 0.15 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.40 Pain Relevance 0.57
We could show increased mRNA expression levels of both IL-23 and IL-17 upon TNBS treatment, which were greatly reduced by Lr32-pulsed DCs.
Positive_regulation (increased) of IL-23
6) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 1.08 Pain Relevance 0.29
In contrast, these two nucleotides are ineffective as enhancers of IL-23; ADP, however, is as effective as ATP at enhancing E. coli-induced IL-23 output.
Positive_regulation (induced) of IL-23
7) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.08
IL-23 is composed of the IL-12p40 and a p19 subunit and likewise binds to a receptor with one of the IL-12 receptor subunits (IL-12R?
Positive_regulation (composed) of IL-23
8) Confidence 0.11 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.43 Pain Relevance 0.25
In this study, splenocytes from DO11.10 T-cell antigen receptor (TCR) transgenic mice activated with ovalbumin peptide preferentially produced IL-22, but not the related cytokines, IL-19, IL-20 or IL-24, after IL-23 stimulation.
Positive_regulation (stimulation) of IL-23 in T-cell associated with targeted disruption and cytokine
9) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.11 Pain Relevance 0.37
produce high levels of IL-12 and IL-23 [18] combined with low levels of IL-10
Positive_regulation (levels) of IL-23
10) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.65 Pain Relevance 0.22
However, our data are consistent with recent evidence showing that bioactive IL-23 (p19/p40) was barely detectable in joints of patients with RA [47].
Positive_regulation (bioactive) of IL-23 in joints associated with rheumatoid arthritis
11) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.33 Pain Relevance 0.14
plus IL-6, human Th17 cell development appears to be independent of these cytokines but requires IL-23 and IL-1?
Positive_regulation (requires) of IL-23 in Th17 cell associated with cytokine
12) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.62 Pain Relevance 0.34
In contrast, these two nucleotides are ineffective as enhancers of IL-23; ADP, however, is as effective as ATP at enhancing E. coli-induced IL-23 output.
Positive_regulation (enhancers) of IL-23
13) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.07
First, substitution of prostaglandin E2 (PGE2) for ATP in the dendritic cell system produces a similar outcome with respect to inhibition of IL-12 and augmention of IL-23 output [63, 65].
Positive_regulation (augmention) of IL-23 in dendritic cell
14) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.12
Activation of adenylate cyclase and the associated rise in cAMP levels appear to be responsible for both the ATP-induced rise in IL-23 and decline in IL-12 from E. coli-induced human dendritic cells.
Positive_regulation (induced) of IL-23 in dendritic cells
15) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.12
Both murine and human Th17 cells require IL-23 for their expansion and survival.
Positive_regulation (require) of IL-23 in Th17 cells
16) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.94 Pain Relevance 0.39
In response to this challenge, IL-12p40, IL-12p35, and IL-23p19 message levels increase and levels of IL-12 and IL-23 released extracellularly increase accordingly [65].
Positive_regulation (increase) of IL-23p19
17) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.15
Although H.pylori-associated gastritis coincides with a marked mucosal induction of IL17 and IL23 [140], and these cytokines are also elevated in gastric cancer bearing gp130Y757F mice (Putoczki T, Ernst M: A role for IL17 in a mouse model of gastric cancer, submitted), the latter tumours also develop in gp130Y757F;Rag-/- mice in the absence of adaptive immune cells [141].
Positive_regulation (induction) of IL23 in immune cells associated with cancer, gastritis, stomach cancer and cytokine
18) Confidence 0.07 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.87 Pain Relevance 0.15
-glucan components of C. albicans will trigger host immune cell responses, and signalling is thought to be mediated through the Syk kinase pathway and the transmembrane adaptor caspase recruitment domain 9 (CARD9) leading to induction of the cytokines IL-23 and IL-6, but not IL-12 [34].
Positive_regulation (induction) of IL-23 in immune cell associated with cytokine
19) Confidence 0.07 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.16 Pain Relevance 0.12
Due to the presence of T cells and sporadic numbers of dendritic cells and macrophages within infiltrates, an increase in the levels of proinflammatory cytokines such as interleukin-17 (IL-17), IL-22, and IL-23 was also detected locally and systemically.
Positive_regulation (increase) of IL-23 in dendritic cells associated with cytokine
20) Confidence 0.05 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.24 Pain Relevance 0.05

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