INT150040

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.43
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf) molecular_function (Vwf) response to stress (Vwf)
Anatomy Link Frequency
plasma 4
Vwf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
epidural 1 94.24 High High
anesthesia 3 93.88 High High
Regional anesthesia 2 75.00 Quite High
cytokine 3 64.52 Quite High
Inflammation 5 64.16 Quite High
Angina 8 50.00 Quite Low
cva 3 25.00 Low Low
chemokine 1 13.04 Low Low
antagonist 12 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 2 100.00 Very High Very High Very High
Cv General 3 Under Development 9 97.80 Very High Very High Very High
Pulmonary Hypertension 150 93.80 High High
Hypertrophy 36 93.20 High High
Disease 9 93.00 High High
Hemorrhage 3 92.48 High High
INFLAMMATION 8 64.16 Quite High
Apoptosis 4 58.36 Quite High
Adhesions 2 31.24 Quite Low
Hypoxia 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After consultation with the hematologist well ahead of the conception, appropriate laboratory workup including clotting factor levels including FVIII, vWF:RcoF, vWF:Ag on different occasions peripartum, and provision of adequate prophylactic medical treatment, she underwent Cesarean section under epidural anesthesia without neurological or bleeding complications. von Willebrand disease is the most common inherited bleeding disorder that may result in various bleeding complications in a parturient as a result of hemostatic challenges during pregnancy.
Negative_regulation (clotting) of Gene_expression (levels) of vWF associated with coagulation disorder, anesthesia, epidural, hemorrhage and disease
1) Confidence 0.30 Published 2009 Journal J Ark Med Soc Section Abstract Doc Link 19475813 Disease Relevance 0.80 Pain Relevance 0.38
It displays its effect on protecting vascular endothelia and anti-angina pectoris partially by decreasing the plasma levels of ET, vWF, sVCAM-1 and sICAM-1 and elevating the level of NO.


Negative_regulation (decreasing) of Gene_expression (levels) of vWF in plasma
2) Confidence 0.22 Published 2009 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19338157 Disease Relevance 0 Pain Relevance 0
MATERIALS AND METHODS: Plasma VWF and ADAMTS13 levels (mU/ml) were measured in 45 patients with UA, 55 with stable exertional angina (SEA) and 47 with chest pain syndrome (CPS) at the time of coronary angiography.
Negative_regulation (measured) of Gene_expression (levels) of VWF in Plasma
3) Confidence 0.13 Published 2008 Journal Thromb. Res. Section Body Doc Link 18295305 Disease Relevance 0.19 Pain Relevance 0
These rMSCs retained the expression of von Willebrand factor and ?
Negative_regulation (retained) of Gene_expression (expression) of von Willebrand factor
4) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.44 Pain Relevance 0.06

General Comments

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