INT150048

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ins1, Rps6kb1) mitochondrion (Rps6kb1) aging (Rps6kb1)
carbohydrate metabolic process (Ins1) extracellular space (Ins1) signal transduction (Rps6kb1)
Anatomy Link Frequency
muscle 1
Ins1 (Rattus norvegicus)
Rps6kb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 3 87.92 High High
cytokine 1 49.12 Quite Low
Inflammation 3 48.72 Quite Low
anesthesia 2 25.00 Low Low
ketamine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 2 99.32 Very High Very High Very High
Hyperplasia 4 93.48 High High
Hypothermia 4 81.00 Quite High
Cardiovascular Disease 2 77.08 Quite High
Postoperative Complications 1 74.08 Quite High
Diabetes Mellitus 7 57.92 Quite High
Increased Venous Pressure Under Development 1 56.12 Quite High
Adhesions 1 51.52 Quite High
INFLAMMATION 3 48.72 Quite Low
Injury 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data from our recent studies suggest that the administration of an AA mixture during anaesthesia stimulates muscle protein synthesis via insulin-mTOR-dependent activation of the translation initiation factors, 4E-BP 1 and S6K1, as a result of increased insulin concentrations.
insulin Positive_regulation (activation) of S6K1 in muscle associated with hyperinsulinism
1) Confidence 0.23 Published 2008 Journal Asia Pac J Clin Nutr Section Abstract Doc Link 18296365 Disease Relevance 0.46 Pain Relevance 0
Insulin and angiotensin II are known to activate the PI3K/Akt/mTOR/P70S6K pathways and to phosphorylate 4E-BP1.13-15
Insulin Positive_regulation (activate) of P70S6K
2) Confidence 0.14 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.37 Pain Relevance 0.04

General Comments

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