INT150050

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.44
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtor, Rps6kb1) cytoplasm (Mtor, Rps6kb1) nucleus (Mtor, Rps6kb1)
aging (Rps6kb1) Golgi apparatus (Mtor) endoplasmic reticulum (Mtor)
Anatomy Link Frequency
muscle 1
Mtor (Rattus norvegicus)
Rps6kb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 10 82.04 Quite High
Hippocampus 25 73.20 Quite High
Lasting pain 22 64.08 Quite High
hyperexcitability 22 52.96 Quite High
Central nervous system 2 25.68 Quite Low
anesthesia 2 25.00 Low Low
Pain 18 20.08 Low Low
c fibre 32 5.00 Very Low Very Low Very Low
Spinal cord 28 5.00 Very Low Very Low Very Low
wide dynamic range 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 1 99.32 Very High Very High Very High
Stress 3 99.00 Very High Very High Very High
Amnesia 3 86.20 High High
Hypothermia 4 80.68 Quite High
Cancer 2 80.24 Quite High
Neurodegenerative Disease 2 79.36 Quite High
Disease 3 75.52 Quite High
Postoperative Complications 1 73.76 Quite High
Pain 40 63.20 Quite High
Increased Venous Pressure Under Development 1 55.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data from our recent studies suggest that the administration of an AA mixture during anaesthesia stimulates muscle protein synthesis via insulin-mTOR-dependent activation of the translation initiation factors, 4E-BP 1 and S6K1, as a result of increased insulin concentrations.
mTOR Positive_regulation (activation) of S6K1 in muscle associated with hyperinsulinism
1) Confidence 0.49 Published 2008 Journal Asia Pac J Clin Nutr Section Abstract Doc Link 18296365 Disease Relevance 0.46 Pain Relevance 0
p70S6K is activated by phosphorylation at Thr-389 solely via mTOR and it is widely used as a readout of mTOR activity [13]–[15], [21], [43].
mTOR Positive_regulation (activated) of p70S6K
2) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.09 Pain Relevance 0.04
These pathways involve mTOR-dependent activation of the 70 kDa ribosomal protein S6 kinase (p70S6K) as well as the inactivation of the repressor of mRNA translation, eukaryotic initiation factor 4E (eIF4E) binding protein (4EBP) [1,2].
mTOR Positive_regulation (activation) of p70S6K
3) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2699332 Disease Relevance 0.45 Pain Relevance 0.13
These pathways involve mTOR-dependent activation of the 70 kDa ribosomal protein S6 kinase (p70S6K) as well as the inactivation of the repressor of mRNA translation, eukaryotic initiation factor 4E (eIF4E) binding protein (4EBP) [1,2].
mTOR Positive_regulation (activation) of 70 kDa ribosomal protein S6 kinase
4) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2699332 Disease Relevance 0.45 Pain Relevance 0.13

General Comments

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