INT150069

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1, Cnr2) plasma membrane (Cnr1, Cnr2) signal transducer activity (Cnr1, Cnr2)
aging (Cnr1)
Anatomy Link Frequency
cerebellum 1
Cnr1 (Mus musculus)
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 100.00 Very High Very High Very High
Cannabinoid receptor 5 99.96 Very High Very High Very High
agonist 4 99.76 Very High Very High Very High
Cannabinoid 8 99.60 Very High Very High Very High
opioid receptor 2 98.16 Very High Very High Very High
Opioid 1 95.24 Very High Very High Very High
cannabis 1 93.44 High High
antinociception 1 91.28 High High
Inflammation 1 81.28 Quite High
Neuropathic pain 1 79.84 Quite High
Disease Link Frequency Relevance Heat
Nociception 1 98.40 Very High Very High Very High
Targeted Disruption 8 95.24 Very High Very High Very High
INFLAMMATION 1 81.28 Quite High
Neuropathic Pain 3 79.84 Quite High
Pain 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have suggested a role for both CB1 and CB2 cannabinoid receptors in modulation of nociception.
CB1 Regulation (role) of CB2 associated with nociception and cannabinoid receptor
1) Confidence 0.50 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19538975 Disease Relevance 0.61 Pain Relevance 0.74
The goal of this study was to evaluate whether acute treatments by endogenous cannabinoid agonist, selective CB1 or CB2 receptor antagonists modulate the expression of mu- (MOR) and delta- (DOR) opioid receptor mRNA levels and functional activity in the cerebellum of transgenic mice deficient in the CB1 type of cannabis receptors.
CB1 Regulation (modulate) of CB2 in cerebellum associated with targeted disruption, cannabis, antagonist, cannabinoid, agonist and opioid receptor
2) Confidence 0.38 Published 2007 Journal Acta. Biol. Hung. Section Abstract Doc Link 18297798 Disease Relevance 0.22 Pain Relevance 0.68

General Comments

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