INT150074

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.30
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (WNT5A) extracellular space (WNT5A) extracellular region (WNT5A)
proteinaceous extracellular matrix (WNT5A) plasma membrane (WNT5A) embryo development (WNT5A)
Anatomy Link Frequency
synovium 2
joint 1
chondrocyte 1
fibroblasts 1
WNT5A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 4 98.92 Very High Very High Very High
Kinase C 6 98.16 Very High Very High Very High
Inflammation 5 96.68 Very High Very High Very High
Chronic pancreatitis 9 94.36 High High
cytokine 18 90.72 High High
vincristine 1 61.04 Quite High
cINOD 16 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 5 99.60 Very High Very High Very High
Malignant Neoplastic Disease 5 99.52 Very High Very High Very High
Rheumatoid Arthritis 11 98.92 Very High Very High Very High
Disease 40 98.44 Very High Very High Very High
Arthritis 5 98.40 Very High Very High Very High
Choroideremia 166 97.80 Very High Very High Very High
Pancreatic Cancer 15 97.76 Very High Very High Very High
Cancer 95 97.44 Very High Very High Very High
INFLAMMATION 8 96.68 Very High Very High Very High
Pancreatitis 9 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of the involved signal transduction pathways revealed a number of genes associated with the Wnt pathway of which the differential expression of SFRP1 and WNT5a was confirmed using immunohistochemistry.
Gene_expression (expression) of WNT5a
1) Confidence 0.75 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18298655 Disease Relevance 1.23 Pain Relevance 0.28
The overexpression of WNT5a, a gene involved in the non canonical Wnt signalling and chondrocyte development might contribute to the strong desmoplastic reaction seen in pancreatic cancer.
Gene_expression (overexpression) of WNT5a in chondrocyte associated with pancreatic cancer
2) Confidence 0.75 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18298655 Disease Relevance 0.98 Pain Relevance 0.24
Moreover, we could demonstrate that WNT5a expression was induced in fibroblasts during cocultivation with a pancreatic carcinoma cell line.
Gene_expression (expression) of WNT5a in fibroblasts associated with pancreatic cancer
3) Confidence 0.75 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18298655 Disease Relevance 1.21 Pain Relevance 0.27
Furthermore, Wnt5a expression in human melanoma biopsies directly correlated with increasing tumor grade [51].
Gene_expression (expression) of Wnt5a associated with cancer and skin cancer
4) Confidence 0.29 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.11 Pain Relevance 0.08
Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.
Gene_expression (expression) of WNT5A associated with choroideremia
5) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.77 Pain Relevance 0.06
It is postulated that the presence of activated synoviocytes in the rheumatoid arthritic joint may be due to the migration of MSCs into the tissue, accompanied by high expression of Wnt-5a.
Gene_expression (expression) of Wnt-5a in joint associated with arthritis
6) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.34 Pain Relevance 0.09
Wnt-5a is expressed constitutively in pellet cultures in vitro (GBoland et al., unpublished observation), whereas in rheumatoid arthritis, there is an established connection between elevated expression of Wnt-5a by activated synovium and established disease markers [90].
Gene_expression (expression) of Wnt-5a in synovium associated with rheumatoid arthritis and disease
7) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.35 Pain Relevance 0.08
Wnt-5a is expressed constitutively in pellet cultures in vitro (GBoland et al., unpublished observation), whereas in rheumatoid arthritis, there is an established connection between elevated expression of Wnt-5a by activated synovium and established disease markers [90].
Gene_expression (expressed) of Wnt-5a in synovium associated with rheumatoid arthritis and disease
8) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.33 Pain Relevance 0.08

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