INT150075

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.53
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (WNT5A) extracellular space (WNT5A) extracellular region (WNT5A)
proteinaceous extracellular matrix (WNT5A) plasma membrane (WNT5A) embryo development (WNT5A)
Anatomy Link Frequency
chondrocyte 2
fibroblasts 2
synovium 2
WNT5A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 99.10 Very High Very High Very High
Inflammation 2 96.68 Very High Very High Very High
Chronic pancreatitis 6 90.04 High High
cytokine 4 70.80 Quite High
dexamethasone 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 2 99.52 Very High Very High Very High
Rheumatoid Arthritis 1 99.10 Very High Very High Very High
Disease 4 98.44 Very High Very High Very High
Pancreatic Cancer 10 98.24 Very High Very High Very High
INFLAMMATION 3 96.68 Very High Very High Very High
Cancer 8 95.32 Very High Very High Very High
Pancreatitis 6 90.04 High High
Arthritis 1 88.80 High High
Adenocarcinoma 6 69.28 Quite High
Cleidocranial Dysplasia 1 59.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we could demonstrate that WNT5a expression was induced in fibroblasts during cocultivation with a pancreatic carcinoma cell line.
Positive_regulation (induced) of Gene_expression (expression) of WNT5a in fibroblasts associated with pancreatic cancer
1) Confidence 0.67 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18298655 Disease Relevance 1.21 Pain Relevance 0.27
The overexpression of WNT5a, a gene involved in the non canonical Wnt signalling and chondrocyte development might contribute to the strong desmoplastic reaction seen in pancreatic cancer.
Spec (might) Positive_regulation (overexpression) of Gene_expression (overexpression) of WNT5a in chondrocyte associated with pancreatic cancer
2) Confidence 0.67 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18298655 Disease Relevance 0.98 Pain Relevance 0.24
Wnt-5a is expressed constitutively in pellet cultures in vitro (GBoland et al., unpublished observation), whereas in rheumatoid arthritis, there is an established connection between elevated expression of Wnt-5a by activated synovium and established disease markers [90].
Positive_regulation (elevated) of Gene_expression (expression) of Wnt-5a in synovium associated with rheumatoid arthritis and disease
3) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.35 Pain Relevance 0.08

General Comments

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