INT150081

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 19
Disease Relevance 1.56
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Ccm2) cytoplasm (Ccm2)
Anatomy Link Frequency
embryos 5
Ccm2 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 3 93.68 High High
cva 1 88.20 High High
Central nervous system 2 82.88 Quite High
cINOD 16 41.28 Quite Low
cytokine 32 39.84 Quite Low
depression 16 5.00 Very Low Very Low Very Low
imagery 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 32 97.36 Very High Very High Very High
Headache Disorders 2 94.00 High High
Epilepsy 3 93.24 High High
Stroke 2 92.68 High High
Headache 1 89.96 High High
Hemorrhage 1 88.20 High High
Stress 128 84.72 Quite High
Vascular Malformations 1 80.96 Quite High
INFLAMMATION 16 41.04 Quite Low
Reprotox - General 3 16 35.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Qualitative RT-PCR methods resulted in the detection of mRNA transcripts encoding Ccm2, Map3k3, Map2k3, Map2k6 and Map2k4 producing the expected size amplicons of 371 bp, 374 bp, 387 bp, 395 bp and 363 bp respectively throughout mouse preimplantation development in all 3 experimental replicates (Figure 2A).
Gene_expression (producing) of Ccm2
1) Confidence 0.77 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.07 Pain Relevance 0
To explore a possible mechanism for the induction of p38 MAPK following incubation in hyperosmotic medium we next examined the influence of exposure to hyperosmotic medium on Ccm2 expression.
Gene_expression (expression) of Ccm2
2) Confidence 0.77 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Relative abundance of mRNAs encoding Ccm2, Map3k3, Map2k3, Map2k6, Map2k4 and Mapk14 during mouse preimplantation development
Gene_expression (encoding) of Ccm2
3) Confidence 0.66 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Cellular distribution of CCM2, MAP3K3, phosphorylated MAP2K3/MAP2K6 and phosphorylated MAP2K4 proteins during mouse preimplantation development
Gene_expression (distribution) of CCM2
4) Confidence 0.66 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
The present study was conducted to investigate whether CCM2 and upstream p38 MAPK pathway constituents are expressed during preimplantation development and to determine whether changes in CCM2 expression are associated with p38 MAPK activation following exposure of preimplantation embryos to hyperosmotic stimuli.
Gene_expression (expression) of CCM2 in embryos
5) Confidence 0.66 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.09 Pain Relevance 0
Despite this outcome, we next investigated whether CCM2 protein levels may be affected.
Gene_expression (levels) of CCM2 protein
6) Confidence 0.66 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Our results indicate that CCM2 is expressed throughout mouse preimplantation development and its protein levels are elevated in response to hypertonic culture conditions and correlate with increased p38 MAPK activity in the early embryo.


Gene_expression (expressed) of CCM2 in embryo
7) Confidence 0.66 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.09 Pain Relevance 0
In conclusion, we have demonstrated for the first time that transcripts and polypeptides encoding MAP3K3, MAP2K3, MAP2K6, MAP2K4 and CCM2 are expressed and localized throughout mouse preimplantation development.
Gene_expression (expressed) of CCM2
8) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
An increase in detectable CCN2 protein without an increase in mRNA levels suggests that 0.2 M sorbitol treatment increases CCM2 expression at the translational level, requiring de novo protein synthesis.
Gene_expression (expression) of CCM2
9) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Our results indicate that Ccm2 along with upstream p38 MAPK pathway constituents (Map3k3, Map2k3, Map2k6, and Map2k4) are expressed throughout mouse preimplantation development.
Gene_expression (expressed) of Ccm2
10) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1781062 Disease Relevance 0.09 Pain Relevance 0
Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation

Background

Gene_expression (expression) of CCM2 in embryo
11) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Title Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
The present study was conducted to investigate whether CCM2 is expressed during mouse preimplantation development and to determine whether this scaffolding protein is associated with p38 MAPK activation following exposure of preimplantation embryos to hyperosmotic environments.


Gene_expression (expressed) of CCM2 in embryos
12) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1781062 Disease Relevance 0.10 Pain Relevance 0
CCM2, MAP3K3 and the phosphorylated forms of MAP2K3/MAP2K6 and MAP2K4 were also detected throughout preimplantation development.
Gene_expression (detected) of CCM2
13) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1781062 Disease Relevance 0.08 Pain Relevance 0
The present study was conducted to investigate whether CCM2 and upstream p38 MAPK pathway constituents are expressed during preimplantation development and to determine whether changes in CCM2 expression are associated with p38 MAPK activation following exposure of preimplantation embryos to hyperosmotic stimuli.
Gene_expression (expressed) of CCM2 in embryos
14) Confidence 0.58 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.10 Pain Relevance 0
Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex.
Gene_expression (deletion) of CCM2
15) Confidence 0.55 Published 2008 Journal Hum. Mutat. Section Title Doc Link 18300272 Disease Relevance 0.28 Pain Relevance 0.09
This would explain the significantly elevated RSS of CCM2 immunofluorescence detected in the sorbitol-treated blastocysts when compared with glycerol-treated and control blastocysts.
Gene_expression (detected) of CCM2
16) Confidence 0.52 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
The CCM2:p.P11_K68del protein could be expressed in cell culture and complexed with CCM3.
Gene_expression (expressed) of CCM2
17) Confidence 0.43 Published 2008 Journal Hum. Mutat. Section Abstract Doc Link 18300272 Disease Relevance 0.16 Pain Relevance 0.05
The CCM genes are identified as Krit 1 (CCM1), MGC4607 (CCM2), and PDCD10 (CCM3).
Gene_expression (identified) of CCM2
18) Confidence 0.32 Published 2010 Journal Neurosurg Rev Section Abstract Doc Link 19760287 Disease Relevance 0.35 Pain Relevance 0.21
Primer pairs were designed and synthesized (Sigma-Aldrich Canada Ltd., Oakville, ON, Canada) for Ccm2, Map3k3, Map2k3, Map2k6, Map2k4, and H2afz based on mouse nucleotide sequences in the Ensembl mouse transcript database.
Gene_expression (synthesized) of Ccm2
19) Confidence 0.29 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox