INT150083

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Krit1) protein complex (Krit1)
Krit1 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 2 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache Disorders 2 96.20 Very High Very High Very High
Epilepsy 2 95.44 Very High Very High Very High
Stroke 2 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex.
Positive_regulation (formation) of CCM1 Binding (complex) of
1) Confidence 0.24 Published 2008 Journal Hum. Mutat. Section Title Doc Link 18300272 Disease Relevance 0.29 Pain Relevance 0.10
These data are in agreement with a loss-of-function mechanism for CCM mutations, uncover an N-terminal CCM2 domain required for CCM1 binding, and demonstrate full-length CCM2 as the essential core protein in the CCM1/CCM2/CCM3 complex.
Positive_regulation (required) of CCM1 Binding (binding) of
2) Confidence 0.21 Published 2008 Journal Hum. Mutat. Section Abstract Doc Link 18300272 Disease Relevance 0 Pain Relevance 0

General Comments

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