INT150085

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.85
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Ccm2) cytoplasm (Ccm2)
Ccm2 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 6 95.88 Very High Very High Very High
cytokine 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache Disorders 6 96.20 Very High Very High Very High
Epilepsy 6 95.44 Very High Very High Very High
Stroke 6 94.88 High High
Stress 8 11.44 Low Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Reprotox - General 3 1 5.00 Very Low Very Low Very Low
Shock 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, its ability to interact with CCM1 and to form a CCM1/CCM2/CCM3 complex was lost.
CCM2 Binding (interact) of
1) Confidence 0.39 Published 2008 Journal Hum. Mutat. Section Abstract Doc Link 18300272 Disease Relevance 0.10 Pain Relevance 0
If 0.2 M sorbitol treatment results in the increased binding of CCM2 protein with its scaffolding partners, it could result in decreased proteolysis and degradation of CCM2 protein.
CCM2 protein Binding (binding) of
2) Confidence 0.35 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex.
CCM2 Binding (complex) of
3) Confidence 0.30 Published 2008 Journal Hum. Mutat. Section Title Doc Link 18300272 Disease Relevance 0.29 Pain Relevance 0.10
A further mutation affected the 3' splice site of CCM2 intron 2 leading to cryptic splice site utilization in both CCM2 and its transcript variant lacking exon 2.
CCM2 Binding (leading) of
4) Confidence 0.30 Published 2008 Journal Hum. Mutat. Section Abstract Doc Link 18300272 Disease Relevance 0.23 Pain Relevance 0.08
However, its ability to interact with CCM1 and to form a CCM1/CCM2/CCM3 complex was lost.
CCM2 Binding (complex) of
5) Confidence 0.29 Published 2008 Journal Hum. Mutat. Section Abstract Doc Link 18300272 Disease Relevance 0 Pain Relevance 0
These data are in agreement with a loss-of-function mechanism for CCM mutations, uncover an N-terminal CCM2 domain required for CCM1 binding, and demonstrate full-length CCM2 as the essential core protein in the CCM1/CCM2/CCM3 complex.
CCM2 Binding (binding) of
6) Confidence 0.29 Published 2008 Journal Hum. Mutat. Section Abstract Doc Link 18300272 Disease Relevance 0 Pain Relevance 0
A further mutation affected the 3' splice site of CCM2 intron 2 leading to cryptic splice site utilization in both CCM2 and its transcript variant lacking exon 2.
CCM2 Binding (utilization) of
7) Confidence 0.26 Published 2008 Journal Hum. Mutat. Section Abstract Doc Link 18300272 Disease Relevance 0.23 Pain Relevance 0.08

General Comments

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