INT15010

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Context Info
Confidence 0.27
First Reported 1990
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.27

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isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
Poly 2
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 21 99.78 Very High Very High Very High
ketamine 1 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1 37.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since this effect was reproduced using three different anesthetics (Avertin, ether, and Ketamine/Xylazan), the inhibition of inducible NK activity is probably due to the state of general anesthesia, rather than to the pharmacological properties of the anesthetics.
Negative_regulation (inhibition) of Positive_regulation (inducible) of NK associated with anesthesia and ketamine
1) Confidence 0.27 Published 1990 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 2116248 Disease Relevance 0 Pain Relevance 0.83
We have previously reported that general anesthesia (Avertin) inhibits the induction of natural killer (NK) cell activity following administration of Poly I:C in vivo.
Negative_regulation (inhibits) of Positive_regulation (induction) of NK in Poly associated with anesthesia
2) Confidence 0.21 Published 1991 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 1712686 Disease Relevance 0 Pain Relevance 0.45

General Comments

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