INT150107

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gck) nucleoplasm (Gck) mitochondrion (Gck)
nucleus (Gck) carbohydrate metabolic process (Gck) kinase activity (Gck)
Anatomy Link Frequency
beta cells 1
Gck (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 2 64.24 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Prostatitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 11 96.72 Very High Very High Very High
Necrosis 1 95.84 Very High Very High Very High
Body Weight 6 78.00 Quite High
Hyperglycemia 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low
Nephritis 1 5.00 Very Low Very Low Very Low
Kidney Stones 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucokinase and pyruvate kinase mRNA levels were significantly decreased, whereas pyruvate dehydrogenase kinase isozyme 4 expression was increased 30-fold; this suggested decreased glycolytic activity.
Negative_regulation (decreased) of Glucokinase
1) Confidence 0.31 Published 2008 Journal Hepatology Section Abstract Doc Link 18302288 Disease Relevance 0 Pain Relevance 0.12
On the other hand, alloxan has two distinct pathological effects: it selectively inhibits glucose-induced insulin secretion through specific inhibition of glucokinase, the glucose sensor of the beta cell, and it causes a state of insulin-dependent diabetes by selective necrosis of beta cells in type 1 and type 2 diabetes mellitus [24-26].
Negative_regulation (inhibition) of glucokinase in beta cells associated with necrosis and diabetes mellitus
2) Confidence 0.16 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2785813 Disease Relevance 0.89 Pain Relevance 0

General Comments

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