INT15011

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1984
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 29
Total Number 29
Disease Relevance 12.47
Pain Relevance 13.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
Poly 5
T cell 4
GPI 2
NK cells 2
macrophages 1
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 10 100.00 Very High Very High Very High
opiate 5 100.00 Very High Very High Very High
Physical dependence 4 100.00 Very High Very High Very High
Morphine 24 99.98 Very High Very High Very High
Potency 4 99.98 Very High Very High Very High
Arthritis 292 99.64 Very High Very High Very High
anesthesia 63 99.52 Very High Very High Very High
ketamine 3 99.42 Very High Very High Very High
cytokine 19 99.02 Very High Very High Very High
agonist 8 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 4 100.00 Very High Very High Very High
Immunization 114 99.90 Very High Very High Very High
Arthritis 322 99.64 Very High Very High Very High
Disease 141 99.44 Very High Very High Very High
Aging 4 98.94 Very High Very High Very High
Hypersensitivity 54 98.06 Very High Very High Very High
Skin Cancer 36 97.84 Very High Very High Very High
Reprotox - General 2 1 95.72 Very High Very High Very High
Stress 9 95.52 Very High Very High Very High
Sprains And Strains 56 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase of IFN at 48 h coincided with a mild enhancement of NK activity in the spleens, but 24 h after LENK injection, the increased IFN level in plasma was associated with a significant drop of splenic NK activity.
Positive_regulation (enhancement) of NK in plasma associated with enkephalin
1) Confidence 0.47 Published 1996 Journal Res Exp Med (Berl) Section Abstract Doc Link 8739803 Disease Relevance 0 Pain Relevance 1.08
Continuous requirement for Th cells in the pathogenesis of G6PI-induced arthritis
Positive_regulation (requirement) of G6PI associated with arthritis
2) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.61 Pain Relevance 0.51
In addition, morphine-induced suppression of splenic NK activity was antagonized in a dose-dependent manner and, at one dose of naltrexone (10.0 mg/kg), splenic NK activity was augmented.
Positive_regulation (augmented) of NK associated with morphine
3) Confidence 0.41 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182537 Disease Relevance 0 Pain Relevance 1.40
Moreover, the combination of 1.0 mg/kg of naltrexone and 32.0 mg/kg of morphine elevated splenic NK activity.
Positive_regulation (elevated) of NK associated with morphine
4) Confidence 0.41 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182537 Disease Relevance 0 Pain Relevance 1.71
In the GPI, tolerance to and physical dependence on various opiates were induced by direct incubation with an agonist and tolerance and abstinence were assessed after its rapid removal by extensive washing.
Positive_regulation (induced) of GPI in GPI associated with physical dependence, agonist, tolerance and opiate
5) Confidence 0.41 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2366190 Disease Relevance 0.35 Pain Relevance 0.88
The data suggest that (i) anesthesia does not affect the ability of Poly I:C to induce endogenous IFN synthesis (serum IFN levels are unaltered by anesthesia) and (ii) anesthesia is capable of inhibiting stimulation of NK activity induced directly by treatment with IFN either in vivo or in vitro.
Positive_regulation (induced) of NK in Poly associated with anesthesia
6) Confidence 0.39 Published 1991 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 1712686 Disease Relevance 0.07 Pain Relevance 0.69
Since Poly I:C has been shown to increase NK activity through the induction of interferon (IFN), the current study examines the role of IFN in this inhibition.
Positive_regulation (induction) of NK in Poly
7) Confidence 0.39 Published 1991 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 1712686 Disease Relevance 0 Pain Relevance 0.54
Since this effect was reproduced using three different anesthetics (Avertin, ether, and Ketamine/Xylazan), the inhibition of inducible NK activity is probably due to the state of general anesthesia, rather than to the pharmacological properties of the anesthetics.
Positive_regulation (inducible) of NK associated with anesthesia and ketamine
8) Confidence 0.29 Published 1990 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 2116248 Disease Relevance 0 Pain Relevance 0.82
Inhibition of the Poly I:C mediated induction of NK was observed for at least 4 days after anesthesia.
Positive_regulation (induction) of NK in Poly associated with anesthesia
9) Confidence 0.29 Published 1990 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 2116248 Disease Relevance 0 Pain Relevance 1.01
Interestingly, neither anesthesia alone nor anesthesia with surgery were able to significantly decrease splenic NK activity that had been induced with Poly I:C prior to anesthesia.
Positive_regulation (induced) of NK in Poly associated with anesthesia
10) Confidence 0.29 Published 1990 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 2116248 Disease Relevance 0 Pain Relevance 1.03
Co-administration of RU486 and NTX restored both NK cellularity and cytolytic activity.
Positive_regulation (restored) of NK
11) Confidence 0.25 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15664788 Disease Relevance 0.85 Pain Relevance 0.61
These results suggest that (a) ICI 174,864 acts as a selective delta antagonist in the MVD; (b) DPDPE interacts with mu receptors in the MVD but only at very high concentrations, and (c) delta receptors appear not to be of functional importance in the GPI.
Positive_regulation (importance) of GPI in MVD associated with antagonist
12) Confidence 0.23 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2987739 Disease Relevance 0 Pain Relevance 0.59
We have previously reported that general anesthesia (Avertin) inhibits the induction of natural killer (NK) cell activity following administration of Poly I:C in vivo.
Positive_regulation (induction) of NK in Poly associated with anesthesia
13) Confidence 0.23 Published 1991 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 1712686 Disease Relevance 0 Pain Relevance 0.44
This resulted in an augmentation of NK activity when the conditioned animals were reexposed to the saccharin-LiCl CS.
Positive_regulation (augmentation) of NK
14) Confidence 0.19 Published 1988 Journal J. Immunol. Section Abstract Doc Link 2826599 Disease Relevance 0.16 Pain Relevance 0.04
Also, peritoneal macrophages from C3H/Hej mice were stimulated with T. cruzi-derived GPI-mucin and/or IFN-gamma.
Positive_regulation (cruzi-derived) of GPI-mucin in peritoneal macrophages
15) Confidence 0.16 Published 1999 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 10454743 Disease Relevance 0.40 Pain Relevance 0.33
An increase in one amino acid residue, dynorphin-(1-9) to -(1-10) or beta-neo-endorphin to alpha-neo-endorphin, resulted in a large potency increase in GPI and an opposite effect in MVD.
Positive_regulation (increase) of GPI in GPI associated with dynorphin and potency
16) Confidence 0.10 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6327333 Disease Relevance 0 Pain Relevance 0.86
Development of G6PI arthritis is associated with a strong antibody response to G6PI and a weak response to type II collagen
Positive_regulation (response) of G6PI associated with arthritis
17) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 1.95 Pain Relevance 0.35
G6PI is systemically distributed in the body because it is expressed intracellular in all cells as an enzyme of glycolysis and can furthermore be secreted.
Positive_regulation (distributed) of G6PI in body
18) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 0.65 Pain Relevance 0.26
Successful aging was connected with a high NK cytotoxic activity and increased number of the total NK compartment.
Positive_regulation (increased) of NK associated with aging
19) Confidence 0.05 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 1.03 Pain Relevance 0
The analysis of mononuclear cells distribution in deciduas of term placentae revealed significantly increased number of dNK, NK and macrophages [17].
Positive_regulation (increased) of NK in macrophages
20) Confidence 0.02 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1184098 Disease Relevance 0.40 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox