INT150117

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Context Info
Confidence 0.78
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.81
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (P4HB) small molecule metabolic process (P4HB) extracellular region (P4HB)
endoplasmic reticulum (P4HB) plasma membrane (P4HB) lipid metabolic process (P4HB)
Anatomy Link Frequency
pancreatic D cells 2
pituitary 1
P4HB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 40 99.12 Very High Very High Very High
Somatostatin 4 98.66 Very High Very High Very High
cytokine 63 98.28 Very High Very High Very High
nud 2 95.68 Very High Very High Very High
abdominal pain 2 92.88 High High
Inflammatory mediators 1 56.72 Quite High
depression 23 50.00 Quite Low
Pain 2 12.40 Low Low
Neuropathic pain 1 9.76 Low Low
Serotonin 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 1 99.68 Very High Very High Very High
INFLAMMATION 41 99.12 Very High Very High Very High
Diabetes Mellitus 4 96.48 Very High Very High Very High
Dyspepsia 2 95.68 Very High Very High Very High
Metastasis 2 95.16 Very High Very High Very High
Diarrhoea 2 94.80 High High
Abdominal Pain 2 92.88 High High
Disease 13 92.48 High High
Achlorhydria 2 91.60 High High
Anaemia 2 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased concentrations of somatostatin, produced by pancreatic D cells or by intestinal mucosa, inihibit secretion of a number of GIT hormones, endocrine and exocrine pancreatic secretion.
Localization (secretion) of GIT in pancreatic D cells associated with somatostatin
1) Confidence 0.78 Published 2007 Journal Rozhl Chir Section Abstract Doc Link 18303777 Disease Relevance 1.17 Pain Relevance 0.18
Increased concentrations of somatostatin, produced by pancreatic D cells or by intestinal mucosa, inihibit secretion of a number of GIT hormones, endocrine and exocrine pancreatic secretion.
Localization (secretion) of GIT in pancreatic D cells associated with somatostatin
2) Confidence 0.68 Published 2007 Journal Rozhl Chir Section Abstract Doc Link 18303777 Disease Relevance 1.26 Pain Relevance 0.19
and its soluble receptors p55 and p75 — released during infection and inflammation activate the HPA system at the hypothalamic, pituitary, and adrenal level resulting in the release of cortisol as the most important negative feedback signal to prevent an overshoot of the ongoing host defense [42, 89, 96]; glucocorticoids, in turn, suppress the production of pro-inflammatory cytokines.
Localization (released) of p55 in pituitary associated with inflammation, infection and cytokine
3) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 1.38 Pain Relevance 0.54

General Comments

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