INT15012

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 11.64
Pain Relevance 6.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
NK cells 5
Poly 1
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 24 100.00 Very High Very High Very High
Inflammation 39 99.98 Very High Very High Very High
opioid receptor 13 99.98 Very High Very High Very High
Opioid 12 99.82 Very High Very High Very High
analgesia 7 99.76 Very High Very High Very High
Morphine 24 99.70 Very High Very High Very High
methotrexate 2 97.64 Very High Very High Very High
antagonist 15 96.88 Very High Very High Very High
cytokine 51 96.48 Very High Very High Very High
opiate 3 94.28 High High
Disease Link Frequency Relevance Heat
Nicotine Addiction 12 100.00 Very High Very High Very High
Hypoxia 100 99.98 Very High Very High Very High
INFLAMMATION 40 99.98 Very High Very High Very High
Stress 30 99.82 Very High Very High Very High
Infection 88 99.42 Very High Very High Very High
Influenza Virus Infection 9 99.32 Very High Very High Very High
Pancreatic Cancer 162 99.06 Very High Very High Very High
Viral Infection 12 98.92 Very High Very High Very High
Necrosis 6 98.44 Very High Very High Very High
Cancer 216 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results marked the first evidence that DEC1 and hexokinase II were hypoxia-induced in human pancreatic cancer and represented the initial report of hypoxic-regulation of GPI/NLK/AMF in any human system [44].
Regulation (regulation) of AMF associated with hypoxia and pancreatic cancer
1) Confidence 0.60 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.57 Pain Relevance 0
Stress-induced modulation of NK activity during influenza viral infection: role of glucocorticoids and opioids.
Regulation (modulation) of NK associated with stress, influenza virus infection, viral infection and opioid
2) Confidence 0.33 Published 2005 Journal Brain Behav. Immun. Section Title Doc Link 15664788 Disease Relevance 1.06 Pain Relevance 0.37
These experiments were designed to investigate the role that stress-induced GC and opioids have in modulating NK activity during an influenza viral infection.
Regulation (modulating) of NK associated with stress, influenza virus infection, viral infection and opioid
3) Confidence 0.33 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15664788 Disease Relevance 1.08 Pain Relevance 0.40
These results marked the first evidence that DEC1 and hexokinase II were hypoxia-induced in human pancreatic cancer and represented the initial report of hypoxic-regulation of GPI/NLK/AMF in any human system [44].
Regulation (regulation) of NLK associated with hypoxia and pancreatic cancer
4) Confidence 0.26 Published 2003 Journal Mol Cancer Section Body Doc Link PMC150383 Disease Relevance 1.57 Pain Relevance 0
Addition of sigma receptor ligands (10(-11)-10(-5) M) to splenocyte cultures for 24 h did not affect NK activity.
Neg (not) Regulation (affect) of NK
5) Confidence 0.26 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8862129 Disease Relevance 0 Pain Relevance 0.72
A large dose of morphine (100.0 mg/kg) elicited full analgesia and had no effect on splenic NK activity in saline- or naltrexone-pretreated mice.
Neg (no) Regulation (effect) of NK associated with analgesia and morphine
6) Confidence 0.24 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182537 Disease Relevance 0 Pain Relevance 1.58
The effects of anesthesia and surgical procedures on natural killer (NK) cell activity were studied.
Regulation (effects) of NK associated with anesthesia
7) Confidence 0.24 Published 1983 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 6674793 Disease Relevance 0.15 Pain Relevance 0.10
In vitro exposure to corticosterone is known to suppress NK activity directly, whereas in vitro morphine was unable to alter directly NK activity.
Neg (unable) Regulation (alter) of NK associated with morphine
8) Confidence 0.23 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932161 Disease Relevance 0 Pain Relevance 1.26
General anesthesia significantly inhibited the induction of NK activity by Poly I:C, while having no effect on baseline NK.
Neg (no) Regulation (effect) of NK in Poly associated with anesthesia
9) Confidence 0.17 Published 1990 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 2116248 Disease Relevance 0 Pain Relevance 0.72
The restoration of RST-induced suppression of NK activity by RU486 and NTX or FNA suggests that glucocorticoids modulate NK cellularity and opioids that bind to the mu-opioid receptor modulate NK cytotoxicity during periods of stress and viral infection.
Regulation (modulate) of NK associated with stress, viral infection, opioid receptor and opioid
10) Confidence 0.16 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15664788 Disease Relevance 0.89 Pain Relevance 0.53
Interestingly, NK activity stimulated by IFN prior to anesthesia was not significantly altered.
Neg (not) Regulation (altered) of NK associated with anesthesia
11) Confidence 0.15 Published 1991 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 1712686 Disease Relevance 0.09 Pain Relevance 0.70
The final position of the STN target in the axial plane corresponded in 64% of the cases with the STN target having the best MER activity and for the GPi target, this was so in 61% of the cases.
Regulation (target) of GPi
12) Confidence 0.15 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2991152 Disease Relevance 0 Pain Relevance 0.08
There were significant differences in the NK cytotoxic activity and intracellular production of IFN-?
Regulation (differences) of NK
13) Confidence 0.05 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 0.89 Pain Relevance 0.03
Because NK function can be affected by such medications [22], we sought to assess whether the differences in treatment regimens between patients with sJRA and pauciarticular/polyarticular JRA might have contributed to the observed differences in NK function.
Regulation (affected) of NK associated with rheumatoid arthritis
14) Confidence 0.04 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 0.76 Pain Relevance 0.27
These data indicate that an active infection with specific pathogens may affect NK cells functions.
Spec (may) Regulation (affect) of NK in NK cells associated with infection
15) Confidence 0.03 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 1.51 Pain Relevance 0.04
Also inflammation affects NK cell functions; our previous studies showed that high concentration of proinflammatory cytokines correlates with low NK cytotoxic activity [22,23].
Regulation (affects) of NK in NK cell associated with inflammation and cytokine
16) Confidence 0.03 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 1.18 Pain Relevance 0.13
There was no significant effect of smoking and medical treatment on NK cells subsets and functions (p > 0,1).


Neg (no) Regulation (effect) of NK in NK cells associated with nicotine addiction
17) Confidence 0.03 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1878503 Disease Relevance 0.90 Pain Relevance 0
Isolated NK cells and NK cells activated for 40 hours by IL-2 (Proleukin, Chiron) 600 Units/ml were incubated at various effector to target rations with chromium-51 labeled K562 cells, an NK target, for 4 hours at 37°C and cytotoxicity was assessed by the amount of radiolabeled chromium released.
Regulation (target) of NK in NK cells
18) Confidence 0.01 Published 2005 Journal J Transl Med Section Body Doc Link PMC551593 Disease Relevance 0 Pain Relevance 0
Isolated NK cells and NK cells activated for 40 hours by IL-2 (Proleukin, Chiron) 600 Units/ml were incubated at various effector to target rations with chromium-51 labeled K562 cells, an NK target, for 4 hours at 37°C and cytotoxicity was assessed by the amount of radiolabeled chromium released.
Regulation (target) of NK in NK cells
19) Confidence 0.00 Published 2005 Journal J Transl Med Section Body Doc Link PMC551593 Disease Relevance 0 Pain Relevance 0

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