INT150132

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.03
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (CLDN5) plasma membrane (CLDN5)
Anatomy Link Frequency
brain 2
cerebrum 1
brainstem 1
CLDN5 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 6 99.16 Very High Very High Very High
diclofenac 10 96.32 Very High Very High Very High
Inflammation 18 90.76 High High
Hyperalgesia 2 81.96 Quite High
Central nervous system 46 79.04 Quite High
IPN 2 71.44 Quite High
Lasting pain 2 70.48 Quite High
Pain 10 67.64 Quite High
chemokine 18 53.00 Quite High
Nerve growth factor 2 29.68 Quite Low
Disease Link Frequency Relevance Heat
Viral Meningitis 36 99.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 220 99.46 Very High Very High Very High
Dementia 34 97.72 Very High Very High Very High
INFLAMMATION 16 90.76 High High
Hyperalgesia 2 81.96 Quite High
Pressure And Volume Under Development 4 81.28 Quite High
Infection 68 78.60 Quite High
Injury 4 74.48 Quite High
Inflammatory Pain 2 71.44 Quite High
Pain 6 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular zonula occludens (ZO-1) expression is modified in brains of patients with HIV encephalitis [71,84], and loss of occludin and claudin-5 correlates with areas of monocytes infiltration [85].
Negative_regulation (loss) of claudin-5 in brains associated with acquired immune deficiency syndrome or hiv infection and viral meningitis
1) Confidence 0.05 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.33 Pain Relevance 0.08
Interestingly, an increase of active STAT1 and a reduction of claudin-5 were also found in microvessels of brain specimens from HAD patients [112].
Negative_regulation (reduction) of claudin-5 in brain associated with dementia
2) Confidence 0.04 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.69 Pain Relevance 0.11
These permeability changes correlated with up- and down-regulation of the tight junction (TJ) protein claudin-5 in the cerebrum and brainstem, respectively.
Negative_regulation (regulation) of claudin-5 in cerebrum associated with medulla
3) Confidence 0.01 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305016 Disease Relevance 0.50 Pain Relevance 0.76
These permeability changes correlated with up- and down-regulation of the tight junction (TJ) protein claudin-5 in the cerebrum and brainstem, respectively.
Negative_regulation (regulation) of claudin-5 in brainstem associated with medulla
4) Confidence 0.00 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18305016 Disease Relevance 0.50 Pain Relevance 0.76

General Comments

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